4'-ACETAMIDOPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE

[ 分子式 ]:
C₁₆H₁₇ClN₄O₃

[ 分子量 ]:
348.78400

[ 精确质量 ]:
348.09900

[ PSA ]:
117.30000

[ LogP ]:
3.91760

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DG2800520

Inhibition of a tumour protease with 3,4-dichloroisocoumarin, pentamidine-isethionate and guanidino derivatives.

J. Enzym. Inhib. 8(3) , 213-21, (1994)

Guanidinobenzoatase (GB) is a cell surface proteolytic enzyme capable of degrading fibronectin, and is associated with tumour cells and cells capable of migration. The location of active GB in section...

Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates.

J. Med. Chem. 29 , 514, (1986)

The aryl 4-guanidinobenzoate, 4'-nitrophenyl 4-guanidinobenzoate (NPGB), is a potent inhibitor of sperm acrosin, an enzyme with an essential function in the fertilization process. NPGB prevents fertil...

Trypsin inhibitors prevent the progesterone-initiated increase in intracellular calcium required for the human sperm acrosome reaction.

J. Exp. Zool. 258(3) , 384-93, (1991)

Inhibitors of trypsin-like enzymes, benzamidine hydrochloride and 4'-acetamidophenyl 4-guanidinobenzoate (also an inhibitor of other serine proteases), were tested for their effects on the acrosome re...

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