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泛酸

泛酸用途

D-Pantothenic acid(pantothenate)即维生素B5,是水溶性维生素。

泛酸名称

[ CAS 号 ]:
79-83-4

[ 中文名 ]:
D-泛酸

[ 英文名 ]:
D-Pantothenic acid

[中文别名 ]:

[英文别名 ]:

kyselinapantothenova
pantothenic acid
PANTOTHENOIC ACID
d-pantothenicaci
D-(+)-Pantothenic acid
Pantothenic
D-(+)-Pantothenyl alcohol
(+)-Pantothenic acid
(R)-Pantothenate
Pantothenic acid, D- (8CI)

泛酸生物活性

[ 描述 ]:

D-Pantothenic acid(pantothenate)即维生素B5,是水溶性维生素。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

天然产物 >> 其他

[参考文献]

[1]. http://en.wikipedia.org/wiki/Pantothenic_acid

[相关活性小分子]

泛酸物理化学性质

[ 密度 ]:
1.266

[ 沸点 ]:
490.2±55.0 °C at 760 mmHg

[ 熔点 ]:
178-179ºC

[ 分子式 ]:
C₉H₁₇NO₅

[ 分子量 ]:
219.235

[ 闪点 ]:
250.3±31.5 °C

[ 精确质量 ]:
219.110672

[ PSA ]:
106.86000

[ LogP ]:
-0.35

[ 外观性状 ]:
白色或类白色固体

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.510

[ 储存条件 ]:
室温

泛酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RU4729000

CHEMICAL NAME :: Pantothenic acid, D-

CAS REGISTRY NUMBER :: 79-83-4

BEILSTEIN REFERENCE NO. :: 1727064

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H17-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1443 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,32,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2490 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81917 No. of Facilities: 862 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1035 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81917 No. of Facilities: 234 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 4854 (estimated) No. of Female Employees: 52 (estimated)

泛酸安全信息

[ 危害码 (欧洲) ]:
Xi

泛酸合成路线

详细合成路线

泛酸上下游产品

泛酸上游产品

泛酸下游产品

泛酸制备

【方法1】
由于泛酸具有很强的吸湿性，难以结晶，所以通常制成钙盐和钠盐。D-泛酸亦天然存在，具有生理活性，其工业生产方法参见泛酸钙条。
【方法2】
由本多生酸钙与硫酸反应制得。

泛酸