去氢表雄酮硫酸钠盐

去氢表雄酮硫酸钠盐用途

Prasterone is an endogenous steroid hormone that acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working memory and cognition, inhibiting proliferation and migration of cervical cancer cells, increasing expression of various glutamate transporters to suppress seizures, and minimizing gastric acid secretion, lipid peroxidation and ulcer formation.

去氢表雄酮硫酸钠盐名称

[ CAS 号 ]:
78590-17-7

[ 中文名 ]:
去氢表雄酮硫酸钠盐

[ 英文名 ]:
Prasterone

[英文别名 ]:

UNII-E1CR8487EN
Sodium dehydroepiandrosterone sulfate
E1CR8487EN
Prasterone sulfate sodium salt dihydrate
Mylis (TN)

去氢表雄酮硫酸钠盐物理化学性质

[ 分子式 ]:
C₁₉H₃₁NaO₇S

[ 分子量 ]:
426.50000

[ 精确质量 ]:
426.16900

[ PSA ]:
110.34000

[ LogP ]:
4.31590

去氢表雄酮硫酸钠盐MSDS

详细MSDS(安全技术说明书)

去氢表雄酮硫酸钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

去氢表雄酮硫酸钠盐文献

Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate.

J. Mol. Neurosci. 56(4) , 868-77, (2015)

The γ-aminobutyric acid type A receptor (GABAAR) is negatively modulated by two structurally similar neurosteroids, pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS). This study att...

Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors.

Stroke 31 , 1953-1957, (2000)

Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may function as neurotrophic or neuroprotective factors to protect central nervous system (CNS) neurons against a variety of insults, including e...

Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.

J. Med. Chem. 41 , 2604-2613, (1998)

The unnatural enantiomers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate (2), and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate (3), compounds 4-6, respectively, were prepared by total s...

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