5(8H)-Naphthacenone,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-12-imino-1-methoxy-,monohydrochloride, (8S,10S)- (9CI)

名称

[ 英文名 ]:
5(8H)-Naphthacenone,10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,9,10,12-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-12-imino-1-methoxy-,monohydrochloride, (8S,10S)- (9CI)

[英文别名 ]:

5-iminodoxorubicin hydrochloride
5-iminodoxorubicin

物理化学性质

[ 密度 ]:
1.57g/cm3

[ 沸点 ]:
907.6ºC at 760 mmHg

[ 分子式 ]:
C₂₇H₃₁ClN₂O₁₀

[ 分子量 ]:
578.99500

[ 闪点 ]:
502.7ºC

[ 精确质量 ]:
578.16700

[ PSA ]:
212.85000

[ LogP ]:
1.78850

[ 折射率 ]:
1.716

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9457400

CHEMICAL NAME :: 5(8H)-Naphthacenone, 7,9,10,12-tetrahydro-10-((3-amino-2,3,6-trideoxy-alph a-L-lyxo- hexopyranosyl)oxy)-8-(hydroxyacetyl)-12-imino-1-metho xy-6,8,11-trihydroxy-, monohydrochloride, (8S-cis)-

CAS REGISTRY NUMBER :: 77331-69-2

LAST UPDATED :: 198508

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H30-N2-O10.Cl-H

MOLECULAR WEIGHT :: 579.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2100 nmol/L

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,669,1981