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7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin

用途

DCIA是一种荧光染料。DCIA含有香豆素荧光团,并与蛋白质中的游离半胱氨酸特异性结合[1]。

名称

[ CAS 号 ]:
76877-34-4

[ 英文名 ]:
7-Diethylamino-3-[4-(iodoacetamido)phenyl]-4-methylcoumarin

[英文别名 ]:

Demcpi
DCIA

生物活性

[ 描述 ]:

DCIA是一种荧光染料。DCIA含有香豆素荧光团,并与蛋白质中的游离半胱氨酸特异性结合[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Branigan E, et al. Quantification of free cysteines in membrane and soluble proteins using a fluorescent dye and thermal unfolding. Nat Protoc. 2013 Nov;8(11):2090-7.

物理化学性质

[ 密度 ]:
1.531g/cm3

[ 沸点 ]:
658.2ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₂₃IN₂O₃

[ 分子量 ]:
490.33400

[ 闪点 ]:
351.9ºC

[ 精确质量 ]:
490.07500

[ PSA ]:
62.55000

[ LogP ]:
5.06110

[ 折射率 ]:
1.67

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H413

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2932209090

海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.

J. Chromatogr. A. 530(1) , 57-64, (1990)

7-(Diethylamino)-3-[4-[iodoacetyl)amino)phenyl]-4-methylcoumarin (DCIA) and 4-(bromomethyl)-7-methoxycoumarin have been evaluated as fluoropyrimidine-derivatizing agents to be detected using peroxyoxa...

Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during translation.

Biochemistry 31(8) , 2368-75, (1992)

The fate of the amino termini of nascent polyalanine, polyserine, and polylysine was monitored by fluorescence techniques as each was translated on Escherichia coli ribosomes. A coumarin probe was pla...

New fluorochromes for thiols: maleimide and iodoacetamide derivatives of a 3-phenylcoumarin fluorophore.

J. Histochem. Cytochem. 29(2) , 314-6, (1981)

N-(4-(7 - Diethylamino - methylcoumarin - 3 yl)phenyl)maleimide (CPM) and the corresponding iodoacetamide are described. When applied to sections at pH 6 and 9, respectively, the two fluorogens are ve...

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