碘化钠

碘化钠用途

【用途一】
用作制备各类碘化合物的原料，也用于医药、照相等
【用途二】
用作分析试剂和碘的助溶剂，也用于制药工业
【用途三】
用作分析试剂和制备单晶的原料
【用途四】
是制造无机碘化物和有机碘化物的原料。在医药上用作祛痰剂和利尿剂，也用于治疗甲状腺肿病。可用作照相胶片感光剂，碘的助溶剂，也用于配制碘乳剂。
【用途五】
化学工业用作制备无机和有机碘化物的重要原料，也用作碘的助溶剂和用于配制碘乳剂。医药工业用于生产祛痰剂和利尿剂等药物。感光工业用作胶片的感光剂，分析化学中用作点滴分析及其他分析试剂。化学反应中用作氧化剂。当温度低于65．6℃，碘化钠在水溶液中形成含水数目不定的各种水合物。室温下由溶液析出二水物，为无色棱形晶体，-13．5～31．5℃内可析出五水物。与二氧化硫作用，生成相应的稳定化合物。有还原性，可被氧化别氧化，游离出碘。

碘化钠名称

[ CAS 号 ]:
7681-82-5

[ 中文名 ]:
碘化钠

[ 英文名 ]:
Sodium iodide

[中文别名 ]:

碘化鈉

[英文别名 ]:

Jodid sodny
Anayodin
Sodium iodine
Ioduril
natriiiodidum
EINECS 231-679-3
SODIUM MONOIODIDE
Natriumjodid
Soiodin
MFCD00003532

碘化钠物理化学性质

[ 密度 ]:
3.66

[ 沸点 ]:
1300 °C

[ 熔点 ]:
661 °C(lit.)

[ 分子式 ]:
INa

[ 分子量 ]:
149.894

[ 闪点 ]:
1300-1304°C

[ 精确质量 ]:
149.894226

[ 外观性状 ]:
珠子

[ 蒸汽密度 ]:
>1 (vs air)

[ 折射率 ]:
1.7745

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
184 g/100 mL (25 ºC)

碘化钠MSDS

详细MSDS(安全技术说明书)

碘化钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WB6475000

CHEMICAL NAME :: Sodium iodide

CAS REGISTRY NUMBER :: 7681-82-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: I-Na

MOLECULAR WEIGHT :: 149.89

WISWESSER LINE NOTATION :: NA I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,21,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,584,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,105,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 115,551,1964

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2362 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 30,407,1927 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64267 ug/kg/14W-C

TOXIC EFFECTS :: Endocrine - changes in thyroid weight Blood - other changes

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 32,89,1991 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9240 mg/kg

SEX/DURATION :: female 1-43 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - other postnatal measures or effects

REFERENCE :: ADCHAK Archives of Disease in Childhood. (British Medical Journal, POB 560B, Kennebunkport, ME 04046) V.1- 1926- Volume(issue)/page/year: 38,526,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 69120 No. of Facilities: 529 (estimated) No. of Industries: 7 No. of Occupations: 9 No. of Employees: 6918 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 69120 No. of Facilities: 1773 (estimated) No. of Industries: 14 No. of Occupations: 27 No. of Employees: 63333 (estimated) No. of Female Employees: 49362 (estimated)

碘化钠安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H400

[ 警示性声明 ]:
P273-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ WGK德国 ]:
1

[ RTECS号 ]:
WB6475000

[ 海关编码 ]:
2827600000

碘化钠合成路线

详细合成路线

碘化钠上下游产品

碘化钠上游产品

碘化钠下游产品

碘化钠制备

1.八碘化三铁法按碘：铁屑=3．3：1的质量比，先将洗净的铁屑加入反应器内，再加水，加水量与铁屑质量比为7：1。分批加入碘片，由于碘和铁反应时产生大量的热，在反应器外需用冷水冷却，使其温度低于65℃。加入碘片后溶液呈深红棕色，待溶液呈淡绿色后，加入第二批碘，过滤除去铁屑，再加入碘反应生成八碘化三铁。在容器中加入碳酸氢钠溶液，在搅拌下缓慢加入八碘化三铁进行反应，此时有二氧化碳气体逸出。反应溶液经静置，吸出上层清液，蒸发浓缩至70～72°Bé，趁热过滤，经冷却结晶、离心分离、干燥，制得碘化钠成品。其
2.铁屑还原法取理论量的：100%～103%烧碱，加水稀释成10%溶液，于反应器中加热至60～80℃，在搅拌下分次加入定量碘，于80～90℃保温搅拌反应约1h，反应液为棕色，Ph值为6～7，同时有碘酸钠的白色结晶析出。将反应液降温至30℃以下，加入2倍于理论量的铁屑使碘酸钠还原成碘化钠。开始反应较剧烈，待反应缓和后，加热煮沸，继续搅拌反应1～2h，然后用10%烧碱溶液调节Ph值为8，煮沸30min，经冷却、静置过滤，将无色透明滤液蒸发浓缩、析出结晶，再趁热过滤、干燥，制得碘化钠成品。其
3.精制的碳酸氢钠与纯的氢碘酸反应，制得碘化钠溶液。制得的碘化钠溶液呈微碱性。添加微量的碘使呈微黄色，煮沸，再向其中加入硫氢酸，至黄色消失，加热浓缩，放冷则二水合碘化钠的结晶析出。将此二水合物放在蒸发皿上，加少量水使其溶解，加碘使溶液微黄，加热煮沸，开始沸腾时加1～2滴H2S，直至黄色消失，继续加热浓缩，即有无水碘化钠析出。倾去母液，边搅拌边小火加热至水气蒸干，将无水NaI在干燥箱中105℃干燥1～2h之后，再移入盛有碘化钙CaI2的干燥器中冷却。如要除去NaI粉末中的空气和水分，还要加入固体碘化铵NH4I（5%～10%）之后，在氢气流中加热以逐出空气与水，再加热至700℃使其熔融。这样可得到较纯的无水碘化钠。

4.将试剂氢氧化钠加水稀释为10%的溶液，加热至70～80℃，在搅拌下分次少量加入固体碘进行反应：

当溶液对酚酞呈弱碱性时停止加碘。于70～80℃反应温度下保温1h,得棕色反应液，反应终点时pH＝6～7，无固体碘。但有白色碘酸钠结晶析出。将反应液冷至10～20℃，加入理论量２倍的铁屑或铁条，搅拌下使碘酸钠还原为碘化钠：

待反应缓和些，加热煮沸，继续搅拌反应1～2h，用硫酸检验还原完全后加入氢氧化钠溶液至ph＝8，继续煮沸0.5h，根据重金属含量，加入适量硫化氢溶液，待沉淀不再析出，冷却静置过滤。滤液加热蒸发至形成结晶薄膜冷却结晶，离心甩干，最后在70～90℃下干燥，得二水合碘化钠。若要获得无水物，则在蒸发浓缩后，温度维持在40℃以上，析出结晶然后趁热过滤、干燥。

碘化钠海关

[ 海关编码 ]: 2827600000

碘化钠文献

Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.

Bioorg. Med. Chem. 19 , 1847-51, (2011)

A high activity α-carbonic anhydrase (CA, EC 4.2.1.1) has been purified from various tissues of the Antarctic seal Leptonychotes weddellii. The new enzyme, denominated lwCA, has a catalytic activity f...

Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogenSalmonella entericaserovar Typhimurium

Bioorg. Med. Chem. Lett. 21 , 3591-5, (2011)

Two new β-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Salmonella enterica serovar Typhimurium, stCA 1 and stCA 2, were characterized kinetically. The two enzymes possess apprecia...

Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.

Bioorg. Med. Chem. Lett. 22 , 1314-6, (2012)

An α-carbonic anhydrase (CA, EC 4.2.1.1) isolated from the living fossil sponge Astrosclera willeyana, Astrosclerin, was investigated for its inhibition profile with simple inorganic anions, complex a...

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碘化钠