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Piptocarphin F

Piptocarphin F用途

Piptocarphin F (Compound 5) 是一种倍半萜内酯。Piptocarphin F 对人白血病细胞系 HL-60 表现出细胞毒性活性 (IC50=5.69 μmol*L-1)。

Piptocarphin F名称

[ CAS 号 ]:
76215-53-7

[ 英文名 ]:
Piptocarphin F

Piptocarphin F生物活性

[ 描述 ]:

Piptocarphin F (Compound 5) 是一种倍半萜内酯。Piptocarphin F 对人白血病细胞系 HL-60 表现出细胞毒性活性 (IC50=5.69 μmol*L-1)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. LIAO, S.-G., et al. Cytotoxic sesquiterpene lactones from Vernonia bockiana. Chinese Journal of Natural Medicines. 2012 May 20;10(3):230–233.

Piptocarphin F物理化学性质

[ 密度 ]:
1.3g/cm3

[ 沸点 ]:
573.4ºC at 760 mmHg

[ 分子式 ]:
C₂₁H₂₈O₈

[ 分子量 ]:
408.44

[ 闪点 ]:
197ºC

[ 精确质量 ]:
408.17800

[ PSA ]:
111.52000

[ LogP ]:
1.66050

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.565

[ 储存条件 ]:
室温

Piptocarphin F毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD3467000

CHEMICAL NAME :: 2-Propenoic acid, 2-methyl-, 2,4,5,6,7,8,9,10-octahydro-6,7-dihydroxy-6,10-dimethy l-3- (ethoxymethyl)-2-oxo-7,10-epoxycyclodeca(b)furan-4-yl ester, (4S-(4R*,6S*,7S*,10R*,11E))-

CAS REGISTRY NUMBER :: 76215-53-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H28-O8

MOLECULAR WEIGHT :: 408.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5105 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 12,443,1985