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三苯基氯甲烷

三苯基氯甲烷用途

【用途一】
用作头孢类药物中间体
【用途二】
用于合成抗病毒药碘甙。
【用途三】
三苯甲基化试剂

三苯基氯甲烷名称

[ CAS 号 ]:
76-83-5

[ 中文名 ]:
三苯基氯甲烷

[ 英文名 ]:
Triphenylmethyl Chloride

[中文别名 ]:

[英文别名 ]:

TrCl
MFCD00000813
Chlorotriphenylmethane
[chloro-di(phenyl)methyl]benzene
Benzene, 1,1',1''- (chloromethylidyne)tris-
1,1',1"-(chloromethanetriyl)tribenzene
Triphenylmethyl chloride
4-05-00-02497 (Beilstein Handbook Reference)
trityl chloride
1,1',1''-(Chloromethanetriyl)tribenzene

三苯基氯甲烷物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
230-235 ºC (20 mmHg)

[ 熔点 ]:
110-113 ºC

[ 分子式 ]:
C₁₉H₁₅Cl

[ 分子量 ]:
278.775

[ 闪点 ]:
177.9±12.0 °C

[ 精确质量 ]:
278.086243

[ LogP ]:
5.57

[ 外观性状 ]:
白色至黄色固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.608

[ 储存条件 ]:
Store under Nitrogen

[ 水溶解性 ]:
chloroform: 0.1 g/mL, clear

三苯基氯甲烷MSDS

三苯基氯甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA6450000

CHEMICAL NAME :: Methane, chlorotriphenyl-

CAS REGISTRY NUMBER :: 76-83-5

BEILSTEIN REFERENCE NO. :: 0397363

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H15-Cl

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04021

三苯基氯甲烷安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R14;R34;R50/53

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S61

[ 危险品运输编码 ]:
UN 3261 8/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
PA6450000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29036990

三苯基氯甲烷合成路线

三苯基氯甲烷上下游产品

三苯基氯甲烷上游产品

三苯基氯甲烷下游产品

三苯基氯甲烷制备

1.干燥无噻吩的苯与四氯化碳混合冷至0-5℃，加入三氯化铝，搅拌反应中放出大量氯化氢气体。将反应物加入预冷的苯和盐酸的混合物中，在25℃以下水解。反应完毕，分取苯层。加热蒸去苯，冷至40℃、加乙酰氯少许，加热回流片刻。冷却，滤除母液，滤饼用石油醚、苯各洗一次，干燥，即得三苯氯甲烷。

2.将无水三氯化铝加到不含水和噻吩的苯中，混匀，在30～40℃下，边搅拌边分次加入干燥的四氯化碳，然后继续搅拌至反应不再放热，蒸汽保温70～80℃，将混合物回流至氯化氢逸出平缓为止。将6mol／L犔的盐酸加到不含水和噻吩的苯中，混合均匀，快速搅拌下，分次加入上述混合液，进行水解反应，控制水解温度在40℃以下。反应式如下：

分出苯层，水层用冰水稀释，再用苯提取几次，合并提取液，用无水氯化钙干燥，活性炭脱色，过滤后冷却结晶。将结晶溶于加入少许氯乙酰的苯  石油醚的混合溶剂中，进行重结晶，得精制三苯基氯甲烷。

三苯基氯甲烷海关

[ 海关编码 ]: 2903999090

[ 中文概述 ]:
2903999090 其他芳烃卤化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

三苯基氯甲烷文献

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

J. Med. Chem. 51 , 1115-25, (2008)

The human kinesin Eg5 is a potential drug target for cancer chemotherapy. Eg5 specific inhibitors cause cells to block in mitosis with a characteristic monoastral spindle phenotype. Prolonged metaphas...

Thermally robust and porous noncovalent organic framework with high affinity for fluorocarbons and CFCs.

Nat. Commun. 5 , 5131, (2014)

Metal-organic and covalent organic frameworks are porous materials characterized by outstanding thermal stability, high porosities and modular synthesis. Their repeating structures offer a great degre...

Comparative susceptibility of newborn and young rats to six industrial chemicals.

Congenit. Anom. (Kyoto.) 45(4) , 137-45, (2005)

To elucidate the comparative susceptibility of newborn rats to chemicals, newborn and young animals were administered six industrial chemicals by gavage from postnatal days (PND) 4 to 21, and for 28 d...

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