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钩藤碱

钩藤碱用途

钩藤碱 (Rhyncholphylline)是从钩藤中分离到的一种生物碱类化合物,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。

钩藤碱名称

[ CAS 号 ]:
76-66-4

[ 中文名 ]:
钩藤碱

[ 英文名 ]:
Rhynchophylline

[中文别名 ]:

二缩双(三羟基甲酸)

[英文别名 ]:

Mitrinermine
Rhyncophylline
mitrinermin
rhynchophyllin
RHYNCHOLPHYLLINE

钩藤碱生物活性

[ 描述 ]:

钩藤碱 (Rhyncholphylline)是从钩藤中分离到的一种生物碱类化合物,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 其他

[参考文献]

[1]. Dan Yuan, et al. Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism. International Immunopharmacology Volume 9, Issues 13–14, December 2009, Pages 1549–1554

[2]. Houcai Huang, et al. Neuroprotective Effects of Rhynchophylline Against Ischemic Brain Injury via Regulation of the Akt/mTOR and TLRs Signaling Pathways. Molecules 2014, 19 (8): 11196-11210; doi:10.3390/molecules190811196

[3]. Tai-Hyun Kang, et al. Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action. Life Sciences Volume 76, Issue 3, 3 December

[4]. Kinzo Matsumoto, et al. Suppressive effects of isorhynchophylline on 5-HT2A receptor function in the brain: Behavioural and electrophysiological studies. European Journal of Pharmacology Volume 517, Issue 3, 11 July 2005, Pages 191–199

[相关活性小分子]

钩藤碱物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
560.8±50.0 °C at 760 mmHg

[ 熔点 ]:
216°; mp 197-199° (Ban et al., loc. cit.)

[ 分子式 ]:
C₂₂H₂₈N₂O₄

[ 分子量 ]:
384.469

[ 闪点 ]:
293.0±30.1 °C

[ 精确质量 ]:
384.204895

[ PSA ]:
67.87000

[ LogP ]:
3.31

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.596

[ 储存条件 ]:
室温

钩藤碱MSDS

详细MSDS(安全技术说明书)

钩藤碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN1600000

CHEMICAL NAME :: Corynoxan-16-carboxylic acid, 16,17-didehydro-17-methoxy-2-oxo-, methyl ester, (7- beta,16E,20-alpha)-

CAS REGISTRY NUMBER :: 76-66-4

LAST UPDATED :: 198909

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H28-N2-O4

MOLECULAR WEIGHT :: 384.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 134 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 94,17,1989

钩藤碱安全信息

[ 安全声明 (欧洲) ]:
S24/25

[ RTECS号 ]:
GN1600000

[ 海关编码 ]:
29399990

钩藤碱合成路线

详细合成路线

钩藤碱上下游产品

钩藤碱上游产品

钩藤碱下游产品

钩藤碱制备

天然存在于茜草科植物钩藤[Uncaria rhynchophylla (Miq. ) Jacks.]等植物中。可用化学合成法制得。

钩藤碱