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(4-脒苯基)甲磺酰氟盐酸盐

(4-脒苯基)甲磺酰氟盐酸盐用途

p-APMSF是一种丝氨酸酶不可逆抑制剂。p-APMSF对氨基酸、赖氨酸或精氨酸的带正电侧链具有底物特异性。p-APMSF可用于研究胰蛋白酶和凝血酶不可逆的抑制作用。

(4-脒苯基)甲磺酰氟盐酸盐名称

[ CAS 号 ]:
74938-88-8

[ 中文名 ]:
(4-脒苯基)甲磺酰氟盐酸盐

[ 英文名 ]:
4-Amidinophenylmethanesulfonyl fluoride hydrochloride

[中文别名 ]:

[英文别名 ]:

MFCD00036898

(4-脒苯基)甲磺酰氟盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. LauraR, et al. (p-Amidinophenyl)methanesulfonyl fluoride, an irreversible inhibitorof serine proteases. Biochemistry. 1980 Oct 14;19(21):4859-64.

(4-脒苯基)甲磺酰氟盐酸盐物理化学性质

[ 沸点 ]:
405.2ºC at 760 mmHg

[ 熔点 ]:
~205 °C (dec.)

[ 分子式 ]:
C₈H₁₀ClFN₂O₂S

[ 分子量 ]:
252.69

[ 闪点 ]:
198.8ºC

[ 精确质量 ]:
252.013550

[ PSA ]:
92.39000

[ LogP ]:
3.45280

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 50 mM Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.

(4-脒苯基)甲磺酰氟盐酸盐MSDS

详细MSDS(安全技术说明书)

(4-脒苯基)甲磺酰氟盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2925290090

(4-脒苯基)甲磺酰氟盐酸盐海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

(4-脒苯基)甲磺酰氟盐酸盐文献

In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.

J. Pharmacol. Exp. Ther. 352(3) , 471-9, (2015)

Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and select...

Zinc binding activity of human metapneumovirus M2-1 protein is indispensable for viral replication and pathogenesis in vivo.

J. Virol. 89 , 6391-405, (2015)

Human metapneumovirus (hMPV) is a member of the Pneumovirinae subfamily in the Paramyxoviridae family that causes respiratory tract infections in humans. Unlike members of the Paramyxovirinae subfamil...

APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription.

FEBS Lett. 589(4) , 532-9, (2015)

APPL1 is a multifunctional endocytic adaptor which acts at different steps of various signaling pathways. Here we report that APPL1 interacts with Dvl2, a protein known to activate the canonical and n...

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