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泛影酸钠

泛影酸钠用途

Sodium diatrizoate 是一种碘化放射造影剂。

泛影酸钠名称

[ CAS 号 ]:
737-31-5

[ 中文名 ]:
泛影酸钠盐水合物

[ 英文名 ]:
Sodium diatrizoate

[中文别名 ]:

[英文别名 ]:

Sodium 3,5-diacetamido-2,4,6-triiodobenzoate
EINECS 212-004-1
win8308-3
MFCD00051544
Diatrizoate sodium salt
HYPAQUE SODIUM
gastrografin
histopaque
sodium 3,5-bis(acetylamino)-2,4,6-triiodobenzoate
hypaque

泛影酸钠生物活性

[ 描述 ]:

Sodium diatrizoate 是一种碘化放射造影剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[体内研究]

泛影酸钠是碘化放射性对比剂。在吹入泛影酸钠纳米颗粒附聚物后,大鼠肺组织的组织学检查显示没有急性毒性或炎症。泛影酸钠纳米粒子聚集体提供了一种有前景的放射性对比剂,用于安全有效的肺部可视化[1]。

[动物实验]

雌性Sprague-Dawley大鼠（200至250克）饲养在温度和湿度受控的房间中，可自由获取食物和水，并保持12小时光照/黑暗循环。用67.5mg / kg氯胺酮，3.5mg / kg甲苯噻嗪和0.66mg / kg乙酰丙嗪皮下混合物麻醉大鼠。在麻醉下，将大鼠置于加热垫上以维持体温37℃。通过使用干粉吹入器的气管内吹气给予泛影酸钠纳米颗粒附聚物（10mg）。在实验结束时，通过过量吸入异氟醚，然后收获主要器官使大鼠安乐死[1]。

[参考文献]

[1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12.

[相关活性小分子]

泛影酸钠物理化学性质

[ 沸点 ]:
614.1ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₈I₃N₂NaO₄

[ 分子量 ]:
635.895

[ 闪点 ]:
325.2ºC

[ 精确质量 ]:
635.751587

[ PSA ]:
98.33000

[ LogP ]:
1.92670

[ 外观性状 ]:
白色到灰白色粉末

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
H2O: 0.35 g/mL, slightly turbid, colorless

泛影酸钠MSDS

详细MSDS(安全技术说明书)

泛影酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG6125000

CHEMICAL NAME :: Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, monosodium salt

CAS REGISTRY NUMBER :: 737-31-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C11-H8-I3-N2-O4.Na

MOLECULAR WEIGHT :: 635.90

WISWESSER LINE NOTATION :: 1VMR BI DI FI CVO EMV1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20349 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 13200 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 11300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 2000 ppm

REFERENCE :: RADLAX Radiology. (Radiological Soc. of North America, 20th & Northampton Sts., Easton, PA 18042) V.1- 1923- Volume(issue)/page/year: 129,199,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0840 No. of Facilities: 305 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2285 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0840 No. of Facilities: 941 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 22494 (estimated) No. of Female Employees: 15852 (estimated)

泛影酸钠安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG6125000

[ 海关编码 ]:
2924299090

泛影酸钠制备

由苯甲酸经混酸硝化、铁粉还原，50%的一氯化碘碘化，乙酐乙酰化再制成钠盐而得。

泛影酸钠海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%