Demecolcine, N-methyl-
Demecolcine, N-methyl-名称
[ CAS 号 ]:
7336-44-9
[ 英文名 ]:
Demecolcine, N-methyl-
[英文别名 ]:
- N,N-dimethyldeacetylcolchicine
- N-Methyldemecolcine
- N-Deacetyl-N,N-dimethylcolchicine
- Demecolcine,N-methyl
- N,N-Dimethyl-desacetyl-colchicin
- N-Methyl-demecolcin
- Methylademecolcine,N
- N-methyldemocolcine
- COLCHICINE,N-DEACETYL-N,N-DIMETHYL
- N-Methylcolchamine
Demecolcine, N-methyl-物理化学性质
[ 密度 ]:
1.2g/cm3
[ 沸点 ]:
619.7ºC at 760 mmHg
[ 分子式 ]:
C22H27NO5
[ 分子量 ]:
385.45300
[ 闪点 ]:
328.6ºC
[ 精确质量 ]:
385.18900
[ PSA ]:
57.23000
[ LogP ]:
3.29710
[ 折射率 ]:
1.581
Demecolcine, N-methyl-毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0792000
- CHEMICAL NAME :
- Colchicine, N-deacetyl-N,N-dimethyl-
- CAS REGISTRY NUMBER :
- 7336-44-9
- LAST UPDATED :
- 198706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C22-H27-N-O5
- MOLECULAR WEIGHT :
- 385.50
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JN1&1 NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981
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