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米各尼醇

米各尼醇用途

Miglitol是口服的抗糖尿病化合物,能抑制糖复合体分解为葡萄糖。

米各尼醇名称

[ CAS 号 ]:
72432-03-2

[ 中文名 ]:
米各尼醇

[ 英文名 ]:
Miglitol

[中文别名 ]:

米格列醇

[英文别名 ]:

BAY m 1099
Miglitol
Diastabol
EINECS 276-661-6
MFCD00867240
GLYSET
Plumarol
BAY-m-1099
Seibule
N-(2-Hydroxyethyl)moranoline

米各尼醇生物活性

[ 描述 ]:

Miglitol是口服的抗糖尿病化合物,能抑制糖复合体分解为葡萄糖。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Fukaya, N., et al., The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur J Pharmacol, 2009. 624(1-3): p. 51-7.

[2]. Hirata, A., et al., Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. Horm Metab Res, 2009. 41(3): p. 213-20.

[相关活性小分子]

米各尼醇物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
453.7±45.0 °C at 760 mmHg

[ 熔点 ]:
114ºC

[ 分子式 ]:
C₈H₁₇NO₅

[ 分子量 ]:
207.224

[ 闪点 ]:
284.3±27.4 °C

[ 精确质量 ]:
207.110672

[ PSA ]:
104.39000

[ LogP ]:
-1.40

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±2.5 mmHg at 25°C

[ 折射率 ]:
1.598

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
Soluble

米各尼醇MSDS

米各尼醇安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

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米各尼醇文献

Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies.

J. Biol. Chem. 288(19) , 13563-74, (2013)

The enzyme “GluI” is key to the synthesis of critical glycoproteins in the cell.We have determined the structure of GluI, and modeled binding with its unique sugar substrate.The specificity of this in...

Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors.

Carbohydr. Res. 346(17) , 2688-92, (2011)

In humans, both the N-terminal catalytic domain (NtMGAM) and the C-terminal catalytic domain (CtMGAM) of small intestinal maltase glucoamylase (MGAM) are α-glycosidases that catalyze the hydrolysis of...

Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlleddb/dbmice

Biochem. Biophys. Res. Commun. 440(4) , 570-5, (2013)

• Beneficial effects of combination therapy with vildagliptin plus miglitol on glucose tolerance of db/db mice were evaluated. • Postprandial glucose- and incretin response was normalized by the combi...

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