司替罗宁

司替罗宁用途

Stepronin(前列甘氨酸)是一种口服活性祛痰剂(吸入给药优于口服给药)。Stepronin通过减少上皮细胞的Cl-分泌和粘膜下腺的粘液糖蛋白分泌来抑制体外气道分泌[1]。

司替罗宁名称

[ CAS 号 ]:
72324-18-6

[ 中文名 ]:
司替罗宁

[ 英文名 ]:
Stepronin

[中文别名 ]:

[英文别名 ]:

司替罗宁生物活性

[ 描述 ]:

Stepronin(前列甘氨酸)是一种口服活性祛痰剂(吸入给药优于口服给药)。Stepronin通过减少上皮细胞的Cl-分泌和粘膜下腺的粘液糖蛋白分泌来抑制体外气道分泌[1]。

[ 相关类别 ]:

研究领域 >> 内分泌
信号通路 >> 其他 >> 其他

[体外研究]

Stepronin(0.1-100µM；20分钟)以剂量依赖性方式诱导犬气管上皮中ISOP(异丙肾上腺素)诱发的SCC(短路电流)值显著降低[1]。Stepronin(10-100µM；20分钟)以剂量依赖性方式显著抑制犬气管上皮细胞的基础分泌和ISOP诱发的PD(电位差)值[1]。Stepronin(100µM；20分钟)显著抑制ISOP诱导的粘膜下腺体[3H]-糖缀合物分泌[1]。细胞活力测定[1]细胞系：犬气管上皮(来自成年和10至25 kg体重的男女杂种狗)浓度：0.1-100µM；10-100µM培养时间：20分钟(治疗前)结果：显著抑制ISOP诱导的SCC和PD值以及基础分泌。细胞活力测定[1]细胞系：粘膜下腺(来自成年和10至25 kg体重的男女杂种狗)浓度：100µM培养时间：20分钟(治疗前)结果：显著抑制ISOP诱导的[3H]-糖缀合物分泌。

司替罗宁物理化学性质

[ 密度 ]:
1.428 g/cm3

[ 沸点 ]:
521.2ºC at 760 mmHg

[ 熔点 ]:
168-170ºC

[ 分子式 ]:
C10H11NO4S2

[ 分子量 ]:
273.32900

[ 闪点 ]:
269ºC

[ 精确质量 ]:
273.01300

[ PSA ]:
137.01000

[ LogP ]:
1.60170

[ 外观性状 ]:
白色或灰白色结晶

[ 折射率 ]:
1.609

司替罗宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC0813680
CHEMICAL NAME :
Glycine, N-(1-oxo-2-((2-thienylcarbonyl)thio)propyl)-
CAS REGISTRY NUMBER :
72324-18-6
LAST UPDATED :
199201
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C10-H11-N-O4-S2
MOLECULAR WEIGHT :
273.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4242354
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1801 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4242354
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3336 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1511 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4242354
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1584 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
534 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 20,310,1984

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