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l-缬氨酸

l-缬氨酸用途

L-Valine 是二十种蛋白氨基酸中的其中一种。L-Valine是一种必需氨基酸。

l-缬氨酸名称

[ CAS 号 ]:
72-18-4

[ 中文名 ]:
L-缬氨酸

[ 英文名 ]:
L-Valine

[中文别名 ]:

[英文别名 ]:

H-L-VAL-OH
L-Val
L-(S)-valine
MFCD00064220
EINECS 200-773-6
2-aminoisovaleric acid
VALINE,L
L-Valine
L-Val-OH
L-VLA

l-缬氨酸生物活性

[ 描述 ]:

L-Valine 是二十种蛋白氨基酸中的其中一种。L-Valine是一种必需氨基酸。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 其他

研究领域 >> 其他

[相关活性小分子]

l-缬氨酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
213.6±23.0 °C at 760 mmHg

[ 熔点 ]:
315ºC

[ 分子式 ]:
C₅H₁₁NO₂

[ 分子量 ]:
117.146

[ 闪点 ]:
83.0±22.6 °C

[ 精确质量 ]:
117.078979

[ PSA ]:
63.32000

[ LogP ]:
0.20

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.1±0.9 mmHg at 25°C

[ 折射率 ]:
1.461

[ 储存条件 ]:
室温

l-缬氨酸MSDS

l-缬氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YV9361000

CHEMICAL NAME :: Valine, L-

CAS REGISTRY NUMBER :: 72-18-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H11-N-O2

MOLECULAR WEIGHT :: 117.17

WISWESSER LINE NOTATION :: QVYZY1&1 -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5390 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81870 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81870 No. of Facilities: 811 (estimated) No. of Industries: 4 No. of Occupations: 16 No. of Employees: 19343 (estimated) No. of Female Employees: 14342 (estimated)

l-缬氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YV9361000

[ 海关编码 ]:
29224995

l-缬氨酸合成路线

l-缬氨酸上下游产品

l-缬氨酸上游产品

l-缬氨酸下游产品

l-缬氨酸制备

1.可由2-氨基噻唑与氯化对硝基苯磺酰缩合，再经还原而制得。

2.用异丁醛作原料，有多种方法可合成外消旋体缬氨酸。例如异丁醛与氨生成氨基异丁醇，再与氰化氢合成氨基异丁腈，然后水解得到缬氨酸，外消旋本的拆分也有多种方法，例如用酰基-DL-氨基酸的酶进行水解，再利用游离氨基酸与酰化体的溶解度差进行分离。发酵法生产的缬氨酸皆为L-型，无需旋光拆分。发酵法的菌种为产谷氨酸微球菌，产氨短杆菌，大肠杆菌，产气气杆菌。用葡萄糖、尿素、无机盐等培养基。

3.发酵法

4. 烟草：BU，22；FC，21；合成：可由鱼蛋白质等水解、精制而得，也可用化学方法合成。

l-缬氨酸海关

[ 海关编码 ]: 29224995

l-缬氨酸文献

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J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Bee pollen improves muscle protein and energy metabolism in malnourished old rats through interfering with the Mtor signaling pathway and mitochondrial activity.

Nutrients 6(12) , 5500-16, (2014)

Although the management of malnutrition is a priority in older people, this population shows a resistance to refeeding. Fresh bee pollen contains nutritional substances of interest for malnourished pe...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

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