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MeOSuc-AAPV-pNA,发色底物

MeOSuc-AAPV-pNA,发色底物用途

MeOSuc Ala Ala Pro Val pNA是人类白细胞和猪胰腺弹性蛋白酶的敏感荧光底物[1]。

MeOSuc-AAPV-pNA,发色底物名称

[ CAS 号 ]:
70967-90-7

[ 中文名 ]:
N-甲氧基琥珀酰-丙酰氨-丙酰氨-脯酰氨-缬氨酸对硝基酰苯胺

[ 英文名 ]:
MeOSuc-Ala-Ala-Pro-Val-pNA

[中文别名 ]:

[英文别名 ]:

MFCD00077137
N-(Methoxysuccinyl)-Ala-Ala-Pro-Val 4-nitroanilide
MeOSuc-Ala-Ala-Pro-Val-p-NA
N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide
MeO-Suc-Ala-Ala-Pro-Val-(p-nitroanilide)
MeOSuc-AAPV-PNA
EINECS 232-670-7
MeOSuc-Ala-Ala-Pro-Val-pNA

MeOSuc-AAPV-pNA,发色底物生物活性

[ 描述 ]:

MeOSuc Ala Ala Pro Val pNA是人类白细胞和猪胰腺弹性蛋白酶的敏感荧光底物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

对于人类白细胞弹性蛋白酶的反应,MeOSuc Ala Ala Pro Val pNA在0.10 M磷酸盐、0.20 M Mes、0.10 M磷酸酯和0.04 M磷酸盐中的kc/Km值分别为185000、15000、58000和330000 M-1s-1。

[参考文献]

[1]. Castillo MJ, et al. Sensitive substrates for human leukocyte and porcine pancreatic elastase: a study of the merits of various chromophoric and fluorogenic leaving groups in assays for serine proteases. Anal Biochem. 1979 Oct 15;99(1):53-64.

[2]. Ross L. Stein, et al. Catalysis by human leukocyte elastase. Rate-limiting deacylation for specific p-nitroanilides and amides. J. Am. Chem. Soc. 1984, 106, 3, 796-798.

MeOSuc-AAPV-pNA,发色底物物理化学性质

[ 密度 ]:
1.297g/cm3

[ 沸点 ]:
908.4ºC at 760 mmHg

[ 分子式 ]:
C₂₇H₃₈N₆O₉

[ 分子量 ]:
590.62500

[ 闪点 ]:
503.2ºC

[ 精确质量 ]:
590.27000

[ PSA ]:
208.83000

[ LogP ]:
2.33450

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.567

[ 储存条件 ]:
20°C

MeOSuc-AAPV-pNA,发色底物MSDS

MeOSuc-AAPV-pNA,发色底物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

MeOSuc-AAPV-pNA,发色底物合成路线

MeOSuc-AAPV-pNA,发色底物上下游产品

MeOSuc-AAPV-pNA,发色底物上游产品

MeOSuc-AAPV-pNA,发色底物下游产品

MeOSuc-AAPV-pNA,发色底物文献

Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.

Mucosal Immunol. 8 , 896-905, (2015)

Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promote tissue damage. Conversely, mechanisms that cons...

Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones.

PLoS ONE 7 , e32366, (2012)

Neutrophils play an important role in innate immunity by defending the host organism against invading microorganisms. Antimicrobial activity of neutrophils is mediated by release of antimicrobial pept...

Inhibition of elastase by a synthetic cotton-bound serine protease inhibitor: in vitro kinetics and inhibitor release.

Wound Repair Regen. 7(2) , 106-18, (1999)

A cotton-bound serine protease inhibitor of elastase (fiber-inhibitor) has been formulated for in vitro evaluation in chronic wound fluid. As a model to understand the properties of the inhibitor in w...

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