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双环[2.2.2]硫代磷酸叔丁酯

双环[2.2.2]硫代磷酸叔丁酯名称

[ CAS 号 ]:
70636-86-1

[ 中文名 ]:
双环[2.2.2]硫代磷酸叔丁酯

[ 英文名 ]:
TERT-BUTYL-BICYCLO [2.2.2]

[英文别名 ]:

tert-Butylbicyclophosphorothionate
TBPS

双环[2.2.2]硫代磷酸叔丁酯物理化学性质

[ 密度 ]:
1.25g/cm3

[ 沸点 ]:
231.3ºC at 760 mmHg

[ 分子式 ]:
C₈H₁₅O₃PS

[ 分子量 ]:
222.24200

[ 闪点 ]:
93.7ºC

[ 精确质量 ]:
222.04800

[ PSA ]:
69.59000

[ LogP ]:
2.97100

[ 折射率 ]:
1.52

双环[2.2.2]硫代磷酸叔丁酯MSDS

详细MSDS(安全技术说明书)

双环[2.2.2]硫代磷酸叔丁酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TG0782500

CHEMICAL NAME :: Phosphorothioic acid, cyclic O,O,O-ester with 2-(tert-butyl)-2-(hydroxymethyl)-1,3- propanediol

CAS REGISTRY NUMBER :: 70636-86-1

LAST UPDATED :: 199409

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H15-O3-P-S

MOLECULAR WEIGHT :: 222.26

WISWESSER LINE NOTATION :: T66 A B AO EOPOTJ CX1&1&1 FS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 47,287,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 38,1734,1990

双环[2.2.2]硫代磷酸叔丁酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TG0782500

双环[2.2.2]硫代磷酸叔丁酯文献

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.

Eur. J. Med. Chem. 43 , 107-13, (2008)

Allopregnanolone (1) and pregnanolone (2), steroids containing a 17beta-acetyl group, are potent enhancers of GABA (gamma-aminobutyric acid) action at GABAA receptors. Their effects are enantioselecti...

Synthesis and GABAAreceptor activity of A-homo analogues of neuroactive steroids

Eur. J. Med. Chem. 45 , 3063-9, (2010)

A procedure is described for the preparation of A-homo-5-pregnenes via an acid catalyzed rearrangement of cyclopropylcarbinols assisted by microwave irradiation. 3α-Hydroxy and 4α-hydroxy-A-homo-5-pre...

Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates.

Eur. J. Pharmacol. 519(1-2) , 31-42, (2005)

The effects of prolonged exposure to and subsequent withdrawal of the thienotriazolobenzodiazepine etizolam on gamma-aminobutyric acid (GABA) type A receptor gene expression and function were compared...

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