三正丁基氢化锡

三正丁基氢化锡用途

【用途一】
常被用來进行还原性自由基反应，其应用的范围相当广泛，不仅能將化合物上特定的官能基脱去，更可对于具有π鍵的化合物进行加成反应，甚至是高位向及立体选择性的进行分子內或分子间的耦合反应。
【用途二】
还原试剂。广泛地用于还原裂解，分子内环化。

三正丁基氢化锡名称

[ CAS 号 ]:
688-73-3

[ 中文名 ]:
三正丁基氢化锡

[ 英文名 ]:
Tributyltin hydride

[中文别名 ]:

[英文别名 ]:

MFCD00009416
SnBu3H
Tri-n-butyltin hydride
Stannane, tributyl-
Tributyltin hydride
TBTH
Tin, tri-n-butyl-, hydride
Tri-n-butylstannane
Tributylstannic hydride
Tributyltin

三正丁基氢化锡物理化学性质

[ 密度 ]:
1.082 g/mL at 25 °C(lit.)

[ 沸点 ]:
281.5±9.0 °C at 760 mmHg

[ 熔点 ]:
<0ºC

[ 分子式 ]:
C₁₂H₂₇Sn

[ 分子量 ]:
291.061

[ 闪点 ]:
124.0±18.7 °C

[ 精确质量 ]:
292.121307

[ LogP ]:
4.88150

[ 外观性状 ]:
近乎于无色液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
n20/D 1.473(lit.)

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
REACTS

三正丁基氢化锡MSDS

三正丁基氢化锡毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH8675000

CHEMICAL NAME :: Stannane, tri-n-butyl-, hydride

CAS REGISTRY NUMBER :: 688-73-3

BEILSTEIN REFERENCE NO. :: 3587329

LAST UPDATED :: 199712

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C12-H28-Sn

MOLECULAR WEIGHT :: 291.09

WISWESSER LINE NOTATION :: 4-SN-H4&4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1460 mg/m3/10M

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: NDCrc-132,FEB1942 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Sn)/m3;STEL 0.2 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.1 mg(Sn)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,258,1971 OSHA PEL (Gen Indu):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 mg(Sn)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-FINLAND:TWA 0.1 mg(Sn)/m3;STEL 0.3 mg(Sn)/m3;Skin JAN 1993 OEL-FRANCE:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg(Sn)/m3;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 mg(Sn)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL-THAILAND:TWA 0.1 mg(Sn)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Sn)/m3;STEL 0.2 mg(Sn)/m3;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ORGANOTIN COMPOUND-air:10H TWA 0.1 mg(Sn)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

三正丁基氢化锡安全信息

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R10;R15;R21;R25;R36/38;R48/23/25;R50/53

[ 安全声明 (欧洲) ]:
S35-S36/37/39-S45-S60-S61-S62-S36/37-S33-S26-S16

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
WH8675000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29310095

三正丁基氢化锡合成路线

三正丁基氢化锡制备

1.制四正丁基锡〔2〕
在安装有搅拌器、回流冷凝器和滴液漏斗的1升三颈烧瓶中，放入由8摩尔钠制成的钠砂和适量石油醚加热至沸。在搅拌下，从滴液漏斗中慢慢地加入1摩尔无水四氯化锡和4摩尔1一氯丁烷的混合物，历时约30分钟。反应很快就开始，停止外部加热，在0.5-1.5小时内反应热使混合物沸腾(45-70℃)。
在沸腾后，继续搅摔4一6小时，然后将反应混合物冷至室温。吸滤。用石油醚洗涤滤饼(含氯化钠和少量未反应的钠)。在常压下蒸馏滤液以除去溶剂。残余物为粗四正丁基锡，将其在真空下蒸馏，产率64%。
用正丁基溴化镁与无水四氛化锡反应，也可制得四正丁基锡
2.制三正于基氛化锡
将四正丁基锡和129克(58毫升)无水四氯化锡的混合物加热至220一230℃，历1.5小时。然后冷却，先在空气中冷至约100℃，在水中冷至30℃。冷却过程约需45分钟。再加热至220-230℃1.5小时。过滤反应混合物，将滤液在真空下蒸馏，收集I40-152℃/10mm馏分，得680g.

3.制氢化三正丁基踢
此步反应在通风橱内氮气流下进行。将19.2克(0.059摩尔)三正丁基氯化锡和140毫升乙二醇二甲醚<预先氢化钙处理分馏)在250毫升恒压漏斗中轻轻摇动，使三正丁基氯化锡完全溶解。
也在通风橱巾将装有磁搅拌子的1升三颈烧瓶夹持在铝锅中，然后将铝锅和烧瓶放在电磁搅拌器上，在烧瓶两侧的颈口上安装气体导入管和导出管。在反应过程中不断通入无氧的干燥氮气。导出管的外端与矿油计泡器相连接，通入氮气数分钟之后，由中口加入6.2克(0 .16摩尔)粉末状氢化硼钠，接着加入230毫升纯乙二醇二甲醚。然后把装有三正丁基氯化锡溶液的滴液漏斗装在中间瓶口上，将干冰一丙酮(或冰一盐)加到铝锅中使反应物保持在一11至一10℃。冷却30分钟。在激烈搅拌下于30分钟内滴入兰正丁基氯化锡溶液，即生成白色氯化钠沉淀，滴加完后，让反应混合物在-11至10℃静置10-15分钟。不用过滤，在氮气流下，将全部反应混合物趁冷转移到1升园底烧瓶中。将烧瓶连接于旋转蒸发器_.}井浸入保持在0℃的冷浴内，蒸发器的接受瓶 (1升园底烧瓶)则浸入一80℃的干冰一丙酮浴中。然后将蒸发器与高真空系统相连接，并通过泳持-196℃真空阱浸在盛液氮的Dewar瓶中)，不断抽真空使反应物蒸发‘蒸发出的副产物乙硼烷收集在一196℃的冷阱中。蒸馏完毕，谊系统中充入氮气至常压。乙硼烷用下述方法分解:快速通入氮气流子这只一196℃的冷f}}，再进入与之相串联的一个气密性的冷阱(200-250毫升)和两个各盛100-200毫升丙酮的气体吸收瓶中。让这只一196℃的冷阱缓慢升温至室温，乙硼烷即被氮气流带入丙酬中。生成的二异丙氧基硼烷则用流水分解成无害的硼酸和氢气。
从旋转蒸发器上取下蒸馏瓶。在氮才〔流下，用3份每份25毫升无过氧化物的无水乙醚提取残余物(最好是蒸干的)。乙醚提取物在氮气流下用干燥的砂芯漏斗过滤，滤液在0℃和1m m以下蒸发30-4 0分钟以除去乙醚。得到无色液体产物16.5克(96%)

三正丁基氢化锡海关

[ 海关编码 ]: 2931900090

[ 中文概述 ]:
2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

三正丁基氢化锡文献

Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance.

Antimicrob. Agents Chemother. 52 , 1559-63, (2008)

Gene inactivation and complementation experiments showed that the tripartite AheABC efflux pump of Aeromonas hydrophila extruded at least 13 substrates, including nine antibiotics. The use of phenylal...

Purification and characterisation of two enzymes related to endogenous formaldehyde in Lentinula edodes.

Food Chem. 138(4) , 2174-9, (2013)

In this study, γ-glutamyl transpeptidase (GGT) and l-cysteine sulphoxide lyase (C-S lyase) were purified from the fruiting body of Lentinula edodes in three steps and then characterised. We found that...

Molecular responses in digestive tract of juvenile common carp after chronic exposure to sublethal tributyltin.

Ecotoxicol. Environ. Saf. 109 , 10-4, (2014)

The effect of long-term exposure to tributyltin (TBT) on the intestine-related biochemical biomarkers in common carp was investigated in this study. Fish were exposed at sub-lethal concentrations of T...

更多文献