(S)-(+)-环氧氯丙烷

(S)-(+)-环氧氯丙烷用途

1）用于手性中间体及手性药物的合成
2）作为潜在的代谢调节剂，用以合成脂肪酸氧化抑制剂；用于Macquarimicins 的全合成和大环内酯 RK-397 的全合成；用于对映选择性合成羟基异噁唑烷和 (+)-顺式-sylvaticin（一种有潜力的抗肿瘤剂）的手性结构单元。

(S)-(+)-环氧氯丙烷名称

[ CAS 号 ]:
67843-74-7

[ 中文名 ]:
右旋环氧氯丙烷

[ 英文名 ]:
(S)-(+)-Epichlorhydrin

[中文别名 ]:

[英文别名 ]:

MFCD00005132
EINECS 203-439-8
Oxirane, 2-(chloromethyl)-, (2S)-
T3OTJ B1G &&(S)-(+)- Form
(S)-3-Chloropropylene Oxide
(S)-(+)-Epichlorohydrin
(2S)-2-(Chloromethyl)oxirane
5-17-01-00021 (Beilstein Handbook Reference)
(S)-(+)-2-(CHLOROMETHYL) OXIRANE

(S)-(+)-环氧氯丙烷物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
116.1±0.0 °C at 760 mmHg

[ 熔点 ]:
−57 °C(lit.)

[ 分子式 ]:
C₃H₅ClO

[ 分子量 ]:
92.524

[ 闪点 ]:
33.9±0.0 °C

[ 精确质量 ]:
92.002892

[ PSA ]:
12.53000

[ LogP ]:
0.45

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
3.2 (vs air)

[ 蒸汽压 ]:
22.0±0.2 mmHg at 25°C

[ 折射率 ]:
1.444

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

[ 水溶解性 ]:
insoluble

(S)-(+)-环氧氯丙烷MSDS

(S)-(+)-环氧氯丙烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RR0427100

CHEMICAL NAME :: Oxirane, (chloromethyl)-, (S)-

CAS REGISTRY NUMBER :: 67843-74-7

BEILSTEIN REFERENCE NO. :: 1420784

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H5-Cl-O

MOLECULAR WEIGHT :: 92.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 298,197,1993

(S)-(+)-环氧氯丙烷安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301 + H311 + H331-H314-H317-H350

[ 警示性声明 ]:
P201-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R10;R23/24/25;R34;R43;R45

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 2023 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
TX4900000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2910900090

(S)-(+)-环氧氯丙烷合成路线

(S)-(+)-环氧氯丙烷上下游产品

(S)-(+)-环氧氯丙烷上游产品

(S)-(+)-环氧氯丙烷下游产品

(S)-(+)-环氧氯丙烷海关

[ 海关编码 ]: 2910900090

[ 中文概述 ]:
2910900090. 三节环环氧化物，环氧醇（酚，醚），包括其卤化，磺化，硝化或亚硝化的衍生物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

(S)-(+)-环氧氯丙烷文献

Kinetics of dextran crosslinking by epichlorohydrin: a rheometry and equilibrium swelling study.

Carbohydr. Polym. 92(2) , 1792-8, (2013)

Curing behavior and gel properties of dextran are investigated during its crosslinking by epichlorohydrin (ECH) using rheometry and equilibrium swelling studies. Each ECH/anhydroglucose unit of differ...

Adsorptive decolorization of methylene blue by crosslinked porous starch.

Carbohydr. Polym. 93(2) , 374-9, (2013)

Crosslinked porous starch (CPS) was prepared by two steps. Native starch was crosslinked with epichlorohydrin and then CPS was prepared by hydrolyzing the crosslinked starch with α-amylase. As a biode...

Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001).

Mutat. Res. 512(2-3) , 173-94, (2002)

Ethylene oxide (EtO), propylene oxide (PO) and epichlorohydrin (ECH) are important industrial chemicals widely used as intermediates for various synthetic products. EtO and PO are also environmental p...

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