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4-羟基-5-氟嘧啶

4-羟基-5-氟嘧啶用途

【用途一】
该品为抗肿瘤药物。

4-羟基-5-氟嘧啶名称

[ CAS 号 ]:
671-35-2

[ 中文名 ]:
5-氟-4-羟基嘧啶

[ 英文名 ]:
4-Hydroxy-5-fluorpyrimidine

[中文别名 ]:

[英文别名 ]:

5-fluoro-1H-pyrimidin-6-one
MFCD00223674

4-羟基-5-氟嘧啶物理化学性质

[ 密度 ]:
1.46 g/cm3

[ 沸点 ]:
200.5ºC at 760 mmHg

[ 分子式 ]:
C₄H₃FN₂O

[ 分子量 ]:
114.07800

[ 闪点 ]:
81.6ºC

[ 精确质量 ]:
114.02300

[ PSA ]:
46.01000

[ LogP ]:
0.32130

[ 折射率 ]:
1.369

4-羟基-5-氟嘧啶MSDS

详细MSDS(安全技术说明书)

4-羟基-5-氟嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7450000

CHEMICAL NAME :: 4(1H)-Pyrimidinone, 5-fluoro-

CAS REGISTRY NUMBER :: 671-35-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H3-F-N2-O

MOLECULAR WEIGHT :: 114.09

WISWESSER LINE NOTATION :: T6N CNJ DQ EF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Tumorigenic - active as anti-cancer agent

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Tumorigenic - active as anti-cancer agent

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 28,159,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1435 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Tumorigenic - active as anti-cancer agent

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 175 mg/kg/7D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(6),7,1980

4-羟基-5-氟嘧啶安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 海关编码 ]:
2933599090

4-羟基-5-氟嘧啶上下游产品

4-羟基-5-氟嘧啶上游产品

4-羟基-5-氟嘧啶下游产品

4-羟基-5-氟嘧啶制备

由氟乙酸乙酯经缩合反应而得。将甲醇钠加入干燥的反应锅内，加甲酸乙酯除去甲醇钠中的游离碱。搅拌下常压蒸出甲醇，然后减压蒸馏，直至甲醇钠成为白色粉末，降温至50℃，加入甲苯。再降至10℃下，滴加甲酸乙酯。加完后仍保持10℃以下滴加氟乙酸乙酯，加毕，在20-25℃反应7h，然后降至10℃以下，加入无水甲醇及乙酸甲脒，搅拌至反应物固化，静置过夜。加入盐酸，慢慢加热使固化物溶解。过滤，滤液常压蒸去部分液体，冷却结晶，过滤得到粗品。用无水乙醇重结晶，活性炭脱色，即得5-氟-4-羟基嘧啶。

4-羟基-5-氟嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%