四溴菊酸

四溴菊酸用途

Tralomethrin is an agricultural chemical used as a pyrethroid insecticide. It kills by modifying the gating kinetics of the sodium channels in neurons, increasing the length of time the channel remains open after a stimulus, thereby depolarizing the neuron for a longer period of time. This leads to uncontrolled spasms, paralysis, and eventual death.

四溴菊酸名称

[ CAS 号 ]:
66841-25-6

[ 中文名 ]:
四溴菊酯

[ 英文名 ]:
Tralomethrin

[中文别名 ]:

[英文别名 ]:

Tralomethrine [ISO-French]
EINECS 266-493-1
SAGA
Bengal Fire Ant Killer
Scout X-tra
Tralomethrin [BSI:ISO]
Caswell No. 861AA
TRALOMETHRIN
Scout
Tralomethrine

四溴菊酸物理化学性质

[ 密度 ]:
1.849g/cm3

[ 沸点 ]:
594.316ºC at 760 mmHg

[ 熔点 ]:
138-148ºC

[ 分子式 ]:
C₂₂H₁₉Br₄NO₃

[ 分子量 ]:
665.00700

[ 闪点 ]:
313.231ºC

[ 精确质量 ]:
660.81000

[ PSA ]:
59.32000

[ LogP ]:
7.46098

[ 折射率 ]:
1.641

[ 储存条件 ]:
0-6°C

四溴菊酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ2009500

CHEMICAL NAME :: Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(1,2,2,2-tetrabromoethyl)-, cyano(3-phenoxy phenyl)methyl ester

CAS REGISTRY NUMBER :: 66841-25-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C22-H19-Br4-N-O3

MOLECULAR WEIGHT :: 665.06

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 99 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,829,1991

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 286 mg/m3/4H

TOXIC EFFECTS :: Behavioral - ataxia Behavioral - irritability

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS570555

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,829,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,829,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,829,1991

四溴菊酸安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H410

[ 警示性声明 ]:
P273-P305 + P351 + P338-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
22-36/38-50/53

[ 安全声明 (欧洲) ]:
26-60-61

[ 危险品运输编码 ]:
UN 2588

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

四溴菊酸制备

制备方法一
在四氯化碳溶剂中，二溴菊酸与溴加成，于20℃反应1h，得四溴菊酸，再与氯化亚砜在DMF和石油醚中转化为四溴菊酰氯，然后与α-氰基间苯氧基苯甲醇合成四溴菊酯。
制备方法二
二氯菊酰氯可通过多种途径获得较高产率，四溴菊酯氯可通过二氯菊酰氯与溴交换反应和加成反应制得，再与α-氰基间苯氧基苯甲醇作用合成四溴菊酯。
制备方法三
四溴菊酯与可采用溴氰菊酯在四氯化碳存在下加溴制得。