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花生四烯酸钠

花生四烯酸钠用途

生化研究（体内合成前列腺素PGE2与PGE2α的前体）

花生四烯酸钠名称

[ CAS 号 ]:
6610-25-9

[ 中文名 ]:
花生四烯酸钠盐

[ 英文名 ]:
Sodium (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate

[中文别名 ]:

花生四烯酸钠盐

[英文别名 ]:

Sodium (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate
arachidonic acid sodium salt
MFCD00065458

花生四烯酸钠物理化学性质

[ 沸点 ]:
407.4ºC at 760 mmHg

[ 熔点 ]:
-49.5ºC

[ 分子式 ]:
C₂₀H₃₁NaO₂

[ 分子量 ]:
326.449

[ 闪点 ]:
336.3ºC

[ 精确质量 ]:
326.222168

[ PSA ]:
40.13000

[ LogP ]:
4.88200

[ 外观性状 ]:
白色至灰白色蜡质固体

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
methanol: 50 mg/mL, clear, colorless to faintly yellow

花生四烯酸钠MSDS

详细MSDS(安全技术说明书)

花生四烯酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JX3874000

CHEMICAL NAME :: 5,8,11,14-Eicosatetraenoic acid, sodium salt, (all-Z)-

CAS REGISTRY NUMBER :: 6610-25-9

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H31-O2.Na

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory obstruction Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: THBRAA Thrombosis Research. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 9,67,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 224,369,1983

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory obstruction Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: THBRAA Thrombosis Research. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 9,67,1976

花生四烯酸钠安全信息

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 风险声明 (欧洲) ]:
R19

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
JX3874000

花生四烯酸钠文献

GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy.

Am. J. Physiol. Renal Physiol. 304(11) , F1317-24, (2013)

Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to prevent its development. To probe potential markers and the underlying mechanism of DN, an animal mode...

Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo

Biochem. Pharmacol. 85(10) , 1478-85, (2013)

Hinokitiol is a tropolone-related bioactive compound that has been used in hair tonics, cosmetics, and food as an antimicrobial agent. Recently, hinokitiol has attracted considerable interest because ...

Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.

J. Biol. Chem. 288(40) , 28641-55, (2013)

Prostaglandin endoperoxide H synthase-2 (PGHS-2), also known as cyclooxygenase-2 (COX-2), is a sequence homodimer. However, the enzyme exhibits half-site heme and inhibitor binding and functions as a ...

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