法扎拉滨

法扎拉滨名称

[ CAS 号 ]:
65886-71-7

[ 中文名 ]:
法扎拉滨

[ 英文名 ]:
1b-D-Arabinofuranosyl-5-azacytosine

[中文别名 ]:

[英文别名 ]:

1b-D-Arabinofuranosyl-5-azacytosine
4-Amino-1b-D-arabinofuranosyl-s-triazin-2(1H)-one
Fazarabine
5-azacytosine arabinoside
ara-AC
1-β-D-Arabinofuranosyl-5-azacytosine
5-azaaracytidine

法扎拉滨物理化学性质

[ 密度 ]:
2.1±0.1 g/cm3

[ 沸点 ]:
534.5±60.0 °C at 760 mmHg

[ 熔点 ]:
228-230ºC (decomposes)

[ 分子式 ]:
C₈H₁₂N₄O₅

[ 分子量 ]:
244.205

[ 闪点 ]:
277.0±32.9 °C

[ 精确质量 ]:
244.080765

[ PSA ]:
143.72000

[ LogP ]:
-1.99

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.823

法扎拉滨毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ2854400

CHEMICAL NAME :: s-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-

CAS REGISTRY NUMBER :: 65886-71-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H12-N4-O5

MOLECULAR WEIGHT :: 244.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1557 ug/kg/72H-C

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - agranulocytosis

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,297,1983