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(-)-东莨菪碱氢溴酸盐

(-)-东莨菪碱氢溴酸盐用途

【用途一】
是一个支气管扩张剂，适用于慢性阻塞性肺疾病（COPD）的维持治疗，包括慢性支气管炎和肺气肿，伴随性呼吸困难的维持治疗及急性发作的预防。

(-)-东莨菪碱氢溴酸盐名称

[ CAS 号 ]:
6533-68-2

[ 中文名 ]:
氢溴酸菪胺

[ 英文名 ]:
Scopolamine hydrobromide trihydrate

[中文别名 ]:

[英文别名 ]:

EINECS 204-050-6
Scopolamine hydrobromide
MFCD00150066
Scopolamine hydrobromide trihydrate
Hyoscine hydrobromide trihydrate

(-)-东莨菪碱氢溴酸盐物理化学性质

[ 密度 ]:
1.31 g/cm3

[ 沸点 ]:
460.3ºC at 760 mmHg

[ 熔点 ]:
197-194 °C

[ 分子式 ]:
C₁₇H₂₈BrNO₇

[ 分子量 ]:
438.311

[ 闪点 ]:
232.2ºC

[ 精确质量 ]:
437.104919

[ PSA ]:
89.99000

[ LogP ]:
1.62120

[ 外观性状 ]:
白色至灰白色粉末

[ 折射率 ]:
-25.5 ° (C=5, H2O)

[ 储存条件 ]:
Poison room

[ 稳定性 ]:
Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic.

(-)-东莨菪碱氢溴酸盐MSDS

详细MSDS(安全技术说明书)

(-)-东莨菪碱氢溴酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YM4730000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, 6-beta,7-beta-epoxy-, (-)-tropate (ester), hydrobromide, trihydrate

CAS REGISTRY NUMBER :: 6533-68-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H21-N-O4.Br-H.3H2-O

MOLECULAR WEIGHT :: 438.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1413 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4800 mg/kg/16D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1470 mg/kg/14W-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28800 mg/kg/16D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg/14W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 3500 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 392,61,1997

(-)-东莨菪碱氢溴酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S45-S25-S1

[ 危险品运输编码 ]:
UN1544 6.1/PG 3

[ RTECS号 ]:
YM4550000

[ 危险类别 ]:
6.1

(-)-东莨菪碱氢溴酸盐文献

Dry eye predisposes to corneal neovascularization and lymphangiogenesis after corneal injury in a murine model.

Cornea 33(6) , 621-7, (2014)

Dry eye disease is becoming recognized as an immune-inflammation mediated disorder. Surgical insults such as corneal incision or suture can aggravate dry eye. We sought to determine whether underlying...

Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice.

Pharmacol. Biochem. Behav. 134 , 57-64, (2015)

5-Hydroxymethyl-2-furaldehyde (5-HMF) is a compound derived from the dehydration of certain sugars. The aim of the present study was to evaluate the effect of 5-HMF on the cognitive impairment induced...

Deer bone extract prevents against scopolamine-induced memory impairment in mice.

J. Med. Food 18(2) , 157-65, (2015)

Deer bone has been used as a health-enhancing food as well as an antiaging agent in traditional Oriental medicine. Recently, the water extract of deer bone (DBE) showed a neuroprotective action agains...

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