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胍乙啶单硫酸盐

胍乙啶单硫酸盐用途

Guanethidine是一抗高血压药物,可降低儿茶酚胺的释放。

胍乙啶单硫酸盐名称

[ CAS 号 ]:
645-43-2

[ 中文名 ]:
硫酸胍乙啶

[ 英文名 ]:
Guanethidine sulfate

[中文别名 ]:

[英文别名 ]:

1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1)
EINECS 211-442-0
Iporal
Guanethidine bisulfate
1-[2-(1-Azocanyl)ethyl]guanidine sulfate
2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid
Sanotensin
MFCD00035403
1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1)
1-[2-(Azocan-1-yl)ethyl]guanidine sulfate

胍乙啶单硫酸盐生物活性

[ 描述 ]:

Guanethidine是一抗高血压药物,可降低儿茶酚胺的释放。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80.

[2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43.

[相关活性小分子]

胍乙啶单硫酸盐物理化学性质

[ 沸点 ]:
345.6ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₂₄N₄O₄S

[ 分子量 ]:
296.387

[ 闪点 ]:
162.8ºC

[ 精确质量 ]:
296.151825

[ PSA ]:
148.12000

[ LogP ]:
2.29240

[ 储存条件 ]:
-20°C

胍乙啶单硫酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF3150000

CAS REGISTRY NUMBER :: 645-43-2

LAST UPDATED :: 198809

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H22-N4.H2-O4-S

MOLECULAR WEIGHT :: 296.44

WISWESSER LINE NOTATION :: T8NTJ A2MYZUM &S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,592,1967 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,57,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

胍乙啶单硫酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S25-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
MF3150000

[ 海关编码 ]:
2933990090

胍乙啶单硫酸盐海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%