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PPIase-Parvulin Inhibitor

PPIase-Parvulin Inhibitor用途

PPIase-Parvulin抑制剂是PPIase-Pin1和Pin4的细胞渗透性抑制剂,IC50s分别为1.5和1.0µM【1】。

PPIase-Parvulin Inhibitor名称

[ CAS 号 ]:
64005-90-9

[ 英文名 ]:
PPIase-Parvulin Inhibitor

[英文别名 ]:

IN1141
phenanthroline-(2H,7H)-diacetate
phenanthroline-2,7-diacetate
HIC 016C

PPIase-Parvulin Inhibitor生物活性

[ 描述 ]:

PPIase-Parvulin抑制剂是PPIase-Pin1和Pin4的细胞渗透性抑制剂,IC50s分别为1.5和1.0µM【1】。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24.

PPIase-Parvulin Inhibitor物理化学性质

[ 密度 ]:
1.471g/cm3

[ 沸点 ]:
636.5ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₁₈N₂O₈

[ 分子量 ]:
438.38700

[ 闪点 ]:
338.7ºC

[ 精确质量 ]:
438.10600

[ PSA ]:
130.74000

[ LogP ]:
0.19180

[ 折射率 ]:
1.641

PPIase-Parvulin Inhibitor安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H400

[ 警示性声明 ]:
P273

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

PPIase-Parvulin Inhibitor合成路线

详细合成路线

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PPIase-Parvulin Inhibitor文献

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice.

EJNMMI Res. 5 , 20, (2015)

Over the last decade, an increasing number of studies have been published on the use of amyloid-β (Aβ) PET imaging with different (18)F-radiopharmaceuticals for clinical characterization of Alzheimer'...

Amyloid Beta-Weighted Cortical Thickness: A New Imaging Biomarker in Alzheimer's Disease.

Curr. Alzheimer Res. 12 , 563-71, (2015)

Alzheimer's disease (AD) is the most common neurodegenerative disorder pathologically characterized by amyloid-beta (Aβ) plaques and neurofibrillary tangles. The aggregation of Aβ precedes tau patholo...

Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults.

J. Alzheimers Dis. 46 , 63-73, (2015)

Even low levels of depressive symptoms are associated with an increased risk of cognitive decline in older adults without overt cognitive impairment (CN). Our objective was to examine whether very low...

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