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Etimizol

Etimizol用途

Etimizol(Ethymisole; Antiffine; Ethylnorantifein)可有效地作用于缺氧造成的失忆症。

Etimizol名称

[ CAS 号 ]:
64-99-3

[ 中文名 ]:
Etimizol

[ 英文名 ]:
Etimizol

[英文别名 ]:

aethimizolum
Ethimizol
Ethymisol
Ethymysol
1 ethyl 4,5 bis(methylcarbamoyl)imidazole
Ethylnorantefein
Etimyzol
1-ethyl-4,5-di(N-methylcarbamoyl)-imidazole
Antiffine
Ethimizole

Etimizol生物活性

[ 描述 ]:

Etimizol(Ethymisole; Antiffine; Ethylnorantifein)可有效地作用于缺氧造成的失忆症。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 神经疾病

[参考文献]

[1]. Borisova GIu. Effect of etimizol on instrumental learning in rats. Biull Eksp Biol Med. 1985 Jun;99(6):705-6.

[2]. Trnovec T, et al. Etimizol absorption from the small intestine in dogs: the dependence on dosage. Biull Eksp Biol Med. 1986 Dec;102(12):729-30.

[3]. Vislobokov AI, et al. Elektrophysiological parameters of mollusk neurons under the influence of etimizol. Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(6):917-24.

[相关活性小分子]

Etimizol物理化学性质

[ 密度 ]:
1.26g/cm3

[ 沸点 ]:
563.4ºC at 760 mmHg

[ 分子式 ]:
C₉H₁₄N₄O₂

[ 分子量 ]:
210.23300

[ 闪点 ]:
294.5ºC

[ 精确质量 ]:
210.11200

[ PSA ]:
83.00000

[ LogP ]:
0.77180

[ 折射率 ]:
1.586

[ 储存条件 ]:
-20°C

Etimizol毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4750500

CHEMICAL NAME :: 1H-Imidazole-4,5-dicarboxamide, 1-ethyl-N,N'-dimethyl-

CAS REGISTRY NUMBER :: 64-99-3

BEILSTEIN REFERENCE NO. :: 0525707

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H14-N4-O2

MOLECULAR WEIGHT :: 210.27

WISWESSER LINE NOTATION :: T5N CNJ A2 DVM1 EVM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 20,99,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 42,221,1979

Etimizol安全信息

[ 海关编码 ]:
2934999090

Etimizol海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%