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EDTA二钠

EDTA二钠用途

乙二胺四乙酸二钠是一种螯合剂,用作蛋白酶抑制剂和金属离子清除剂。乙二胺四乙酸二钠广泛用于蛋白质纯化。乙二胺四乙酸二钠已被证明是一种对纤维素酶活性无效的分子。乙二胺四乙酸二钠与包括钙在内的金属结合,促进其排泄[1][2]。

EDTA二钠名称

[ CAS 号 ]:
6381-92-6

[ 中文名 ]:
乙二胺四乙酸二钠盐二水合物

[ 英文名 ]:
Disodium edetate dihydrate

[中文别名 ]:

[英文别名 ]:

DISODIUM EDTA DIHYDRATE
Edetate disodium dihydrate
edta
EDTA disodium salt dihydrate
EDTA disodium dihydrate
EINECS 205-358-3
MFCD00003541
Disodium edetate dihydrate
EDTA-2Na

EDTA二钠生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016;10(1):58-62.

[2]. Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011;412(1):34-39.

EDTA二钠物理化学性质

[ 密度 ]:
1.01 g/mL at 25 °C

[ 沸点 ]:
>100 °C

[ 熔点 ]:
250 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₁₈N₂Na₂O₁₀

[ 分子量 ]:
372.237

[ 闪点 ]:
325.2ºC

[ 精确质量 ]:
372.075684

[ PSA ]:
179.80000

[ 外观性状 ]:
白色粉末或晶体

[ 折射率 ]:
n20/D 1.363

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
soluble

EDTA二钠MSDS

详细MSDS(安全技术说明书)

EDTA二钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH4410000

CHEMICAL NAME :: Acetic acid, (ethylenedinitrilo)tetra-, disodium salt, dihydrate

CAS REGISTRY NUMBER :: 6381-92-6

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H14-N2-O8.2Na.2H2-O

MOLECULAR WEIGHT :: 372.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 200 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,63,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7050 No. of Facilities: 1244 (estimated) No. of Industries: 13 No. of Occupations: 20 No. of Employees: 12572 (estimated) No. of Female Employees: 8163 (estimated)

EDTA二钠安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H332-H373

[ 警示性声明 ]:
P260

[ 靶器官 ]:
Respiratory Tract

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S26-S61-S37/39-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
AH4025000

[ 海关编码 ]:
29224995

EDTA二钠制备

1.按一定的配比将氰化钠与甲醛的混合物缓缓加入乙二胺水溶液中，在85℃、减压下通入空气以除去氨气。反应完毕后，用浓硫酸调Ph值至4. 5，再经脱色、过滤、浓缩、结晶分离、干燥得成品。氯乙酸法
先将100kg氯乙酸、100kg冰和135kg 30%的NaOH溶液混合，在搅拌下加入18kg 83%～84%的乙二胺，在15℃下保温1h。分批缓慢加入30%的NaOH溶液至反应物显碱性为止，并在室温下保持12h。加热至90℃，加活性炭脱色。滤液用盐酸调Ph值到4.5，并在90℃下浓缩、过滤；滤液冷却后结晶、分离、洗涤，在70℃下干燥得成品。

2.用乙二胺四乙酸与氢氧化钠溶液作用制得：在装有搅拌器的2L反应烧瓶中，加入292g乙二胺四乙酸，1.2L水。在搅拌下加入200mL 30%氢氧化钠溶液，加热至全部反应完。加20％的盐酸中和至pH=4.5，加热至90℃浓缩，过滤。滤液冷却后析出结晶。抽滤分出，用蒸馏水洗涤，在70℃烘干，得产品二水乙二胺四乙酸二钠盐。

3.在搪瓷反应罐中加入乙二胺四乙酸、水，在搅拌下加入氢氧化钠溶液，加热至全部反应，加盐酸至PH为4.5，加热至90℃浓缩，过滤，滤液冷却，滤出结晶，水洗，70℃烘干，得乙二胺四乙酸二钠。

4.将氯乙酸钠与乙二胺缩合，经酸化得乙二胺四乙酸，再用氢氧化钠中和即得。把所得粗品溶于10倍水中，加入等体积乙醇以析出二钠盐，然后过滤，洗涤。

EDTA二钠海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

EDTA二钠文献

Differential protective effects of extra virgin olive oil and corn oil in liver injury: a proteomic study.

Food Chem. Toxicol. 74 , 131-8, (2014)

Extra virgin olive oil (EVOO) presents benefits against chronic liver injury induced by hepatotoxins such as carbon tetrachloride (CCl4); however, the protective mechanisms remain unclear. In the pres...

Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination.

Cell. Mol. Life Sci. 71(24) , 4895-910, (2014)

Membrane proteins are key elements in cell physiology and drug targeting, but getting a high-resolution structure by crystallographic means is still enormously challenging. Novel strategies are in big...

Oxidative damage of rat liver mitochondria during exposure to t-butyl hydroperoxide. Role of Ca²⁺ ions in oxidative processes.

Life Sci. 92(23) , 1110-7, (2013)

The present study was designed for further evaluation of the biochemical mechanism of hepatic mitochondrial dysfunction under oxidative damages induced by organic hydroperoxide, tert-butyl hydroperoxi...

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