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L-丙氨酸-3,3,3-d3

L-丙氨酸-3,3,3-d3用途

L-丙氨酸-d3(L-2-氨基丙酸-d3)是氘标记的L-丙氨酸。L-丙氨酸是一种非必需氨基酸,参与糖和酸的代谢,提高免疫力,为肌肉组织、大脑和中枢神经系统提供能量。

L-丙氨酸-3,3,3-d3名称

[ CAS 号 ]:
63546-27-0

[ 中文名 ]:
L-丙氨酸-3,3,3-d3

[ 英文名 ]:
L-Alanine-d3

[英文别名 ]:

MFCD00084107
L-<3,3,3-2H3>alanine
L-(3,3,3-H)Alanine
l-alanine-d3
L-Alanine-3,3,3-d3
L-Alanine-3,3,3-d
alanine-C-d3

L-丙氨酸-3,3,3-d3生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

L-丙氨酸-3,3,3-d3物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
212.9±23.0 °C at 760 mmHg

[ 熔点 ]:
314.5ºC (dec.)(lit.)

[ 分子式 ]:
C₃H₄D₃NO₂

[ 分子量 ]:
92.112

[ 闪点 ]:
82.6±22.6 °C

[ 精确质量 ]:
92.066505

[ PSA ]:
63.32000

[ LogP ]:
-0.68

[ 外观性状 ]:
白色-灰白色固体

[ 蒸汽压 ]:
0.1±0.9 mmHg at 25°C

[ 折射率 ]:
1.460

[ 储存条件 ]:
2-8°C

L-丙氨酸-3,3,3-d3安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

L-丙氨酸-3,3,3-d3合成路线

详细合成路线

L-丙氨酸-3,3,3-d3上下游产品

L-丙氨酸-3,3,3-d3上游产品

L-丙氨酸-3,3,3-d3下游产品

L-丙氨酸-3,3,3-d3文献

Towards the chiral metabolomics: Liquid chromatography-mass spectrometry based DL-amino acid analysis after labeling with a new chiral reagent, (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate, and the application to saliva of healthy volunteers.

Anal. Chim. Acta 875 , 73-82, (2015)

A novel triazine-type chiral derivatization reagent, i.e., (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate (DMT-(S)-Pro-OSu), was developed for the highly s...

Metabolomics study of hepatocellular carcinoma: discovery and validation of serum potential biomarkers by using capillary electrophoresis-mass spectrometry.

J. Proteome Res. 13(7) , 3420-31, (2014)

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. The lack of effective screening methods for early diagnosis has been a longstanding bottleneck to improve the survival rate. In t...

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