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苯并[a]芘-d12

苯并[a]芘-d12用途

苯并[a]芘-d12是氘标记的苯并[a]芘[1]。苯并[a]芘在动物模型中显示出对肺部的致癌性,它经常用于化学预防研究[2][3]。

苯并[a]芘-d12名称

[ CAS 号 ]:
63466-71-7

[ 中文名 ]:
苯并[a]芘-d12

[ 英文名 ]:
benzo[a]pyrene-d12

[中文别名 ]:

[英文别名 ]:

Perdeuteriobenzo<a>pyren
3,4-Benzopyrene-d12

苯并[a]芘-d12生物活性

[ 描述 ]:

苯并[a]芘-d12是氘标记的苯并[a]芘[1]。苯并[a]芘在动物模型中显示出对肺部的致癌性,它经常用于化学预防研究[2][3]。

[ 相关类别 ]:

研究领域 >> 癌症

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30(3): 209–216.

[3]. Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5812:189

苯并[a]芘-d12物理化学性质

[ 密度 ]:
1.348 g/cm3

[ 沸点 ]:
495ºC(lit.)

[ 熔点 ]:
177-180ºC(lit.)

[ 分子式 ]:
C₂₀D₁₂

[ 分子量 ]:
264.38300

[ 闪点 ]:
228.6ºC

[ 精确质量 ]:
264.16900

[ LogP ]:
5.73720

[ 储存条件 ]:
0-6°C

苯并[a]芘-d12MSDS

详细MSDS(安全技术说明书)

苯并[a]芘-d12安全信息

[ 符号 ]:

GHS05, GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H318-H340-H350-H360FD-H410

[ 警示性声明 ]:
P201-P280-P305 + P351 + P338 + P310-P308 + P313

[ 危害码 (欧洲) ]:
T,N

[ 风险声明 (欧洲) ]:
R45

[ 安全声明 (欧洲) ]:
S45-S53-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

苯并[a]芘-d12文献

Pollution biomonitoring in the Bizerte lagoon (Tunisia), using combined chemical and biomarker analyses in grass goby, Zosterisessor ophiocephalus (Teleostei, Gobiidae).

Mar. Environ. Res. 101 , 184-95, (2014)

In this study, biological responses and contaminant levels in biological tissues were investigated in grass goby fish specimens (Zosterisessor ophiocephalus) collected from five stations in a moderate...

Distribution and Sources of Petroleum Hydrocarbons in Recent Sediments of the Imo River, SE Nigeria.

Arch. Environ. Contam. Toxicol. 70 , 372-82, (2016)

The distribution of aliphatic and aromatic hydrocarbons in surface sediments of the lower course of the Imo River (Nigeria) was investigated to determine the sources and fate of these compounds. The a...

The effects of flow rate and temperature on SPMD measurements of bioavailable PAHs in seawater.

Mar. Pollut. Bull. 97 , 217-23, (2015)

This work investigates the dependence of the sampling rate (Rs) of semi-permeable membrane devices (SPMDs) on flow rate and temperature. The in situ Rs values were obtained using performance reference...

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