rac 4-Hydroxydebrisoquine Hemisulfate

rac 4-Hydroxydebrisoquine Hemisulfate名称

[ CAS 号 ]:
62580-84-1

[ 英文名 ]:
rac 4-Hydroxydebrisoquine Hemisulfate

[英文别名 ]:

rac 4-Hydroxydebrisoquine Hemisulfate物理化学性质

[ 熔点 ]:
262-265ºC

[ 分子式 ]:
C₁₀H₁₅N₃O₅S

[ 分子量 ]:
289.30800

[ 精确质量 ]:
289.07300

[ PSA ]:
156.32000

[ LogP ]:
1.59500

[ 储存条件 ]:
2-8°C，密封，干燥

rac 4-Hydroxydebrisoquine HemisulfateMSDS

详细MSDS(安全技术说明书)

rac 4-Hydroxydebrisoquine Hemisulfate安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

rac 4-Hydroxydebrisoquine Hemisulfate文献

Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate.

Biochem. Pharmacol. 58(3) , 439-45, (1999)

The microsomal oxidative transformation of a non-physiological N-hydroxyguanidine was demonstrated for the first time for N-hydroxydebrisoquine as a model substrate (Clement et al., Biochem Pharmacol ...

Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians.

Br. J. Clin. Pharmacol. 45(3) , 315-7, (1998)

To determine the effect of therapeutic loading doses of halofantrine and chloroquine on CYP2D6 activity in healthy black Zambians.Twenty healthy black male Zambians were phenotyped for CYP2D6 activity...

Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship.

Clin. Chem. Lab Med. 43(3) , 275-9, (2005)

The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several clinically important drugs. So far more than 50 different CYP2D6 allelic variants have been described...

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