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DL-高半胱氨酸硫内酯盐酸盐

DL-高半胱氨酸硫内酯盐酸盐用途

用作医药中间体

DL-高半胱氨酸硫内酯盐酸盐名称

[ CAS 号 ]:
6038-19-3

[ 中文名 ]:
DL-高半胱氨酸硫内酯盐酸盐

[ 英文名 ]:
3-Aminodihydro-2(3H)-thiophenone hydrochloride

[中文别名 ]:

[英文别名 ]:

d,l-homocysteinthiolaktonchlorid
Hcy-thiolactone hydrochloride
Homocysteine thiolactone hydrochloride
DL-HOMOCYSTEINE THIOLACTONE HCL
HCTL hydrocloride salt
MFCD00012724
hctlhydrochloride
DL-HOMOCYSTEIN THIOLACTONE HCL
3-Aminodihydro-2(3H)-thiophenone hydrochloride
1,4-thiolactone hydrochloride

DL-高半胱氨酸硫内酯盐酸盐生物活性

[ 描述 ]:

DL-Homocysteine thiolactone hydrochloride 是一种具有根生长抑制活性的环状氨基酸衍生物。

[ 相关类别 ]:

研究领域 >> 其他

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

DL-Homocysteine thiolactone hydrochloride即使在50μM的低浓度下也显示出对Brassica campestris和Echinochloa utilis根的生长抑制[1]。

[参考文献]

[1]. Yoshihiko INAMORI, et al. Root-growth Inhibition by DL-Homocysteine Thiolactone and Its Related Compounds. Biosci. Biotech. Biochem., 59 (3), 523-525, 1995.

[相关活性小分子]

DL-高半胱氨酸硫内酯盐酸盐物理化学性质

[ 密度 ]:
0.862 g/cm3

[ 沸点 ]:
253.8ºC at 760 mmHg

[ 熔点 ]:
202 °C (dec.)(lit.)

[ 分子式 ]:
C₄H₈ClNOS

[ 分子量 ]:
153.630

[ 闪点 ]:
107.3ºC

[ 精确质量 ]:
153.001511

[ PSA ]:
68.39000

[ LogP ]:
1.47950

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
室温

[ 水溶解性 ]:
740.5 g/L (20 C)

DL-高半胱氨酸硫内酯盐酸盐MSDS

DL-高半胱氨酸硫内酯盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XN1928400

CHEMICAL NAME :: 2(3H)-Thiophenone, dihydro-3-amino-, hydrochloride, (+-)-

CAS REGISTRY NUMBER :: 6038-19-3

LAST UPDATED :: 198903

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H7-N-O-S.Cl-H

MOLECULAR WEIGHT :: 153.64

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,72,1958

DL-高半胱氨酸硫内酯盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XN1928400

[ 包装等级 ]:
I; II

[ 危险类别 ]:
6.1

DL-高半胱氨酸硫内酯盐酸盐合成路线

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DL-高半胱氨酸硫内酯盐酸盐文献

Water determination in active pharmaceutical ingredients using ionic liquid headspace gas chromatography and two different detection protocols.

J. Pharm. Biomed. Anal. 94 , 111-7, (2014)

A rapid, accurate, precise and versatile analytical method was developed for the detection and quantification of water in solid active pharmaceutical ingredients (APIs). The headspace gas chromatograp...

Comparison of the effect of homocysteine in the reduced form, its thiolactone and protein homocysteinylation on hemostatic properties of plasma.

Thromb. Res. 127(3) , 214-9, (2011)

Mechanisms involved in the relationship between hyperhomocysteinemia and hemostatic process are still unclear. In the literature there are few papers describing studies on the effects of homocysteine ...

Response of blood platelets to resveratrol during a model of hyperhomocysteinemia.

Platelets 22(4) , 277-83, (2011)

Resveratrol (3,4',5-trihydroxystilben), a phenolic antioxidant synthesized in grapes and other plants, and also present in wine, has been suggested to help prevent cardiovascular events. In this study...

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