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骆驼蓬灵盐酸盐二水合物

骆驼蓬灵盐酸盐二水合物名称

[ CAS 号 ]:
6027-98-1

[ 中文名 ]:
盐酸骆驼蓬灵

[ 英文名 ]:
HARMALINE HYDROCHLORIDE DIHYDRATE

[中文别名 ]:

骆驼蓬灵盐酸盐二水合物

[英文别名 ]:

Harmaline hydrochloride
EINECS 253-734-0
HARMALOL METHYL ETHER HYDROCHLORIDE DIHYDRATE
HARMALINE HCL DIHYDRATE(RG)
MFCD00150052

骆驼蓬灵盐酸盐二水合物物理化学性质

[ 沸点 ]:
426.4ºC at 760 mmHg

[ 熔点 ]:
232-240 °C

[ 分子式 ]:
C₁₃H₁₉ClN₂O₃

[ 分子量 ]:
286.75500

[ 闪点 ]:
211.7ºC

[ 精确质量 ]:
286.10800

[ PSA ]:
55.84000

[ LogP ]:
2.65060

[ 储存条件 ]:
−20°C

骆驼蓬灵盐酸盐二水合物MSDS

详细MSDS(安全技术说明书)

骆驼蓬灵盐酸盐二水合物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MG8750000

CHEMICAL NAME :: Harmaline, hydrochloride, dihydrate

CAS REGISTRY NUMBER :: 6027-98-1

LAST UPDATED :: 199106

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H14-N2-O.Cl-H.2H2-O

MOLECULAR WEIGHT :: 286.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TRSEAO Transactions of the Royal Society of Edinburgh. (Edinburgh, Scotland) V.1-70, 1783-1979. Volume(issue)/page/year: 47,245,1909

骆驼蓬灵盐酸盐二水合物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
1544

[ WGK德国 ]:
3

[ RTECS号 ]:
MG8750000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

骆驼蓬灵盐酸盐二水合物上下游产品

骆驼蓬灵盐酸盐二水合物上游产品

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骆驼蓬灵盐酸盐二水合物海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

骆驼蓬灵盐酸盐二水合物文献

Apomorphine enhances harmaline-induced tremor in rats.

Pharmacol. Rep. 67 , 435-41, (2015)

Harmaline-induced tremor is a well-known model of essential tremor in humans. The aim of the present study was to examine the influence of apomorphine, a non-selective dopamine receptor agonist, on th...

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