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双硫腙

双硫腙用途

二硫腙,用于分析(二苯基硫代氨基偶氮酮)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

双硫腙名称

[ CAS 号 ]:
60-10-6

[ 中文名 ]:
铅试剂

[ 英文名 ]:
Dithizone

[中文别名 ]:

[英文别名 ]:

(E)-N',2-Diphenyldiazenecarbothiohydrazide
Dithizone
Phenyldiazenecarbothioic Acid 2-Phenylhydrazide
MFCD00003025
diphenylthiocarbazone
EINECS 200-454-1

双硫腙生物活性

[ 描述 ]:

二硫腙,用于分析(二苯基硫代氨基偶氮酮)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

双硫腙物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
376.1±25.0 °C at 760 mmHg

[ 熔点 ]:
168°C (dec.)

[ 分子式 ]:
C₁₃H₁₂N₄S

[ 分子量 ]:
256.33

[ 闪点 ]:
181.2±23.2 °C

[ 精确质量 ]:
256.078278

[ PSA ]:
80.87000

[ LogP ]:
4.01

[ 外观性状 ]:
暗蓝色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.644

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶；可溶于：乙醇；微溶：氯仿；极微溶：乙醚

双硫腙MSDS

双硫腙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ9450000

CHEMICAL NAME :: Formic acid, (phenylazo)thio-, 2-phenylhydrazide

CAS REGISTRY NUMBER :: 60-10-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C13-H12-N4-S

MOLECULAR WEIGHT :: 256.35

WISWESSER LINE NOTATION :: RNUNYUS&MMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,44,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#07955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80827 No. of Facilities: 260 (estimated) No. of Industries: 7 No. of Occupations: 9 No. of Employees: 1195 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80827 No. of Facilities: 69 (estimated) No. of Industries: 6 No. of Occupations: 7 No. of Employees: 2298 (estimated) No. of Female Employees: 1324 (estimated)

双硫腙安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S36-S26

[ 危险品运输编码 ]:
2811

[ RTECS号 ]:
LQ9450000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

双硫腙合成路线

双硫腙上下游产品

双硫腙上游产品

双硫腙下游产品

双硫腙制备

1.按下述步骤制备。1.苯肼二硫代甲酸苯肼盐的制备。将13g苯肼溶于60ml乙醚中，滴加5.2ml二硫化碳。将生成的白色沉淀滤出，用乙醚洗涤，得约15g。2.二苯二氨基硫脲的制备。将上述生成物置于烧杯中，在96-98℃的水浴上加热，物料熔融后放出硫化氢而转为淡黄以的胶状物。若有氨气放出，则移出热浴，用水冷却。再用冰冷却。再用冰冷却，加入15ml水无水乙醇，自冰浴中取出，搅拌下稍热，这时胶状物变成结晶状产物，抽滤，用乙醇洗涤，得约7.5g。3.双硫腙的制备。将上述所得二苯二氨基硫脲加到苛性钾溶液（6g氢氧化钾溶于60ml无水甲醇）中，在沸水浴上回流5min，取出在冰浴中冷却。过滤，滤液用硫酸酸化至刚果红试纸变色，析出深蓝色沉淀。抽滤，将沉淀物再用苛性钾溶液、硫酸处理一遍，抽滤后用水洗至无硫酸根存在。在40℃烘干，得双硫腙约3g。

2.将苯肼与甲苯的混合物冷却至0℃以下，在搅拌下加入二硫化碳，并控制加入速度使反应温度维持在60～70℃，放置10min以上，再加热升温至90～95℃，结晶溶解并开始反应。当析出大量结晶并使醋酸铅试剂呈微棕色时，反应结束，冷却后过滤，结晶依次用冷甲苯和乙醇洗涤，所得白色结晶即
为二苯基硫代卡巴肼。然后，将二苯基卡巴肼加到氢氧化钾的甲醇溶液中，加热回流5～10min，冰水冷却至30℃左右，滤去不溶物，边搅拌边向滤液中加入0.5mol／L的硫酸水溶液至溶液对刚
果红试纸恰呈酸性，过滤所得结晶先用冷水洗涤，再溶5%的氢氧化钠溶液，滤去不溶物，滤液用冰水冷却，同时用冷的0.5mol／L的硫酸酸化至刚果红试纸恰呈酸性，沉淀完全后过滤，滤出的结晶用冰水充分洗涤至SO₄^2- 离子合格，抽干后于40℃干燥，即得成品二苯基硫代卡巴腙。过程反应为：

双硫腙文献

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New biocides such as the organometallic compound zinc pyrithione (ZnP) have been massively introduced by many countries in formulations of antifouling paints following the ban on tributyltin (TBT). Th...

Long-term survival of allograft murine islets coated via covalently stabilized polymers.

Adv. Healthc. Mater. 3(7) , 1061-70, (2014)

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Feasibility of islet magnetic resonance imaging using ferumoxytol in intraportal islet transplantation.

Biomaterials 52 , 272-80, (2015)

There is a clinical need for an alternative labeling agent for magnetic resonance imaging (MRI) in islet transplantation. We aimed to evaluate the feasibility of islet MRI using ferumoxytol, which is ...

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双硫腙