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4-阿基苯甲酯

4-阿基苯甲酯用途

用于制偶氮染料和恶嗪染料等，并用作醇溶黄和pH值指示剂

4-阿基苯甲酯名称

[ CAS 号 ]:
60-09-3

[ 中文名 ]:
对氨基偶氮苯

[ 英文名 ]:
Aniline Yellow

[中文别名 ]:

[英文别名 ]:

Benzenamine, 4- (phenylazo)-
4-Aminoazobenzene
Oil soluble Aniline Yellow
Organol Yellow 2A
P-PHENYLAZOANILINE
Benzenamine, 4-[(E)-2-phenyldiazenyl]-
SOLVENT YELLOW 1
Aniline Yellow (VAN)
cellitazol r
EINECS 200-453-6

4-阿基苯甲酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
360.7±15.0 °C at 760 mmHg

[ 熔点 ]:
123-126 °C(lit.)

[ 分子式 ]:
C₁₂H₁₁N₃

[ 分子量 ]:
197.236

[ 闪点 ]:
171.9±20.4 °C

[ 精确质量 ]:
197.095291

[ PSA ]:
50.74000

[ LogP ]:
3.41

[ 外观性状 ]:
橙色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.611

[ 储存条件 ]:
2~8℃

[ 水溶解性 ]:
水溶性：不溶；水溶解度：32 mg/l 25 °C；易溶于：醇,苯,氯仿,乙醚

4-阿基苯甲酯MSDS

4-阿基苯甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY8225000

CHEMICAL NAME :: Aniline, p-(phenylazo)-

CAS REGISTRY NUMBER :: 60-09-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 39

MOLECULAR FORMULA :: C12-H11-N3

MOLECULAR WEIGHT :: 197.26

WISWESSER LINE NOTATION :: ZR DNUNR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 89 gm/kg/57W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1965 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3353 ug/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 296 mg/kg female 15-19 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrarenal

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 32 mg/L

REFERENCE :: NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959- Volume(issue)/page/year: 58,243,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,390,1987 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,53,1975 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-SWEDEN;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82881 No. of Facilities: 28 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 168 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82881 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 737 (estimated)

4-阿基苯甲酯安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H350-H410

[ 警示性声明 ]:
P201-P273-P308 + P313-P501

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;N: Dangerous for the environment;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R45;R50/53

[ 安全声明 (欧洲) ]:
S53-S45-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BY8225000

[ 海关编码 ]:
2927000090

4-阿基苯甲酯合成路线

4-阿基苯甲酯上下游产品

4-阿基苯甲酯上游产品

4-阿基苯甲酯下游产品

4-阿基苯甲酯制备

以苯胺出发，重氮化后再与苯胺缩合经转位重排而得。向反应锅投入苯胺与亚硝酸钠溶液，在30-40℃下搅拌，在2.5-3h内加入30%盐酸，然后升温至50-55℃进行转位。

4-阿基苯甲酯海关

[ 海关编码 ]: 2927000090

[ 中文概述 ]:
2927000090 其他重氮化合物、偶氮化合物等（包括氧化偶氮化合物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

4-阿基苯甲酯文献

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Dermatitis 22(1) , 16-26, (2011)

Hairdressing chemicals may be associated with allergic contact dermatitis.To review our experience of patch-testing with hairdressing chemicals.We reviewed results from patients who underwent patch te...

Transcriptional responses in neonate and adultDaphnia magnain relation to relative susceptibility to genotoxicants

Aquat. Toxicol. 104(3-4) , 192-204, (2011)

Little information is available on the responses of lower animals to genotoxic chemicals or on their sensitivity for detecting genotoxic chemicals, especially at different life-stages, despite the est...

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