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硫氰酸胍

硫氰酸胍用途

【用途一】
主要用于生物医药，化学试剂等
【用途二】
离液剂（Chaotropic agent）和强变性剂，用于变性裂解细胞；提取RNA和DNA。

硫氰酸胍名称

[ CAS 号 ]:
593-84-0

[ 中文名 ]:
硫氰酸胍

[ 英文名 ]:
Guanidine thiocyanate

[中文别名 ]:

[英文别名 ]:

GUANIDINE RHODANIDE
Guanidine, thiocyanate (1:1)
Guandine thiocyanate
thiocyanic acid,guanidine salt
Guanidinethiocyanate
GUANIDINIUM RHODANIDE
MFCD00013027
Guanidine isothiocyanate
Guanidine thiocyanate
Guanidine thiocyanate (1:1)

硫氰酸胍生物活性

[ 描述 ]:

硫氰酸胍是一种致潮剂。硫氰酸胍可以用作蛋白质变性剂和核酸保护剂,用于从细胞中提取DNA和RNA【1】。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Mason PE, et al. The hydration structure of guanidinium and thiocyanate ions: implications for protein stability in aqueous solution. Proc Natl Acad Sci U S A. 2003;100(8):4557-4561.

硫氰酸胍物理化学性质

[ 密度 ]:
1.103 g/mL at 20 °C

[ 沸点 ]:
132.9ºC at 760 mmHg

[ 熔点 ]:
120-122 °C(lit.)

[ 分子式 ]:
C₂H₆N₄S

[ 分子量 ]:
118.16

[ 闪点 ]:
34.2ºC

[ 精确质量 ]:
118.031319

[ PSA ]:
138.48000

[ LogP ]:
0.73618

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
n20/D 1.482

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stability Stable, but light sensitive. Incompatible with acids (contact releases very toxic gas), strong oxidising agents.

[ 水溶解性 ]:
H2O: 6 M at 20 °C, clear, colorless

硫氰酸胍MSDS

详细MSDS(安全技术说明书)

硫氰酸胍毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XL1225000

CAS REGISTRY NUMBER :: 593-84-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C-H5-N3.C-H-N-S

MOLECULAR WEIGHT :: 118.18

WISWESSER LINE NOTATION :: ZYZUM &SHCN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

硫氰酸胍安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312 + H332-H314-H412

[ 补充危害声明 ]:
Contact with acids liberates very toxic gas.

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R32;R52/53

[ 安全声明 (欧洲) ]:
S36/37-S61-S13

[ 危险品运输编码 ]:
1759

[ WGK德国 ]:
2

[ RTECS号 ]:
XL1225000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2925290090

硫氰酸胍上下游产品

硫氰酸胍上游产品

硫氰酸胍下游产品

硫氰酸胍海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

硫氰酸胍文献

Efficient programmable gene silencing by Cascade.

Nucleic Acids Res. 43(1) , 237-46, (2015)

Methods that permit controlled changes in the expression of genes are important tools for biological and medical research, and for biotechnological applications. Conventional methods are directed at i...

Isolation and immortalization of MIP-GFP neurons from the hypothalamus.

Endocrinology 155(6) , 2314-9, (2014)

The mouse insulin I promoter (MIP) construct was developed to eliminate the promoter activity detected with the rat insulin II promoter in specific hypothalamic neurons that may have unintended effect...

Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosis.

MBio 6 , e02428, (2015)

Mycobacterium tuberculosis can persist for decades in the human host. Stringent response pathways involving inorganic polyphosphate [poly(P)], which is synthesized and hydrolyzed by polyphosphate kina...

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