2-巯基苯并咪唑

2-巯基苯并咪唑用途

用途：防老剂MB在橡胶工业上是主要的非污染性防老剂，能减少橡胶硫化时的变色。本品适于制造透明、白色及艳色制品，耐热及泡沫制品，本品不变色，不被污染。
主要用于合成橡胶、顺丁橡胶、丁苯橡胶、丁腈橡胶及乳胶等。
溶于碱性溶液中，M用作镀铜光亮剂，可使镀层光亮，并有整平作用。还可提高工作电流密度。常与N,SPS等配合使用。
该品用作天然橡胶、二烯类合成橡胶及胶乳的抗氧剂，亦可用于聚乙烯。它是一种所谓的二次防老剂，与其他防老剂（如DNP、AP及其他非污染性防老剂）并用，可获得明显的协同效果。该品在橡胶中易分散，在日光下不变色。略有污染性。单独使用时用量和般为1-1.5份，当用量超过2份时，会产生喷霜现象。在乳胶泡沫橡胶中的用量为0.5-1份，在透明橡胶制品中的用量为0.5份。因本品有苦味，不宜用于与食品接触的橡胶制品中。2-巯基苯并咪唑在医药上是一种新抗麻疯药，毒性比砜类药物低，而疗效也底，可产生耐药性，无蓄积作用。可用于不适用砜类药物的患者。2-巯基并咪唑碱金属盐水溶液与水溶性锌盐溶液反应可得2-巯基苯并咪唑锌盐，即防老剂MBZ（C14H10N4S2Zn）。该品无毒。
在橡胶工业上是主要的非污染性防老剂,能减少橡胶硫化时的变色。对防止橡胶空气老化有效,特别适用于制造透明、白色和艳色制品。
本品用作天然橡胶、二烯类合成橡胶及胶乳的抗氧剂，也可用于聚乙烯。对氧、天候老化及静态老化等具有防护效能，也能较有效地防护铜害和克服制晶硫化时过硫引起的不良作用。本品可单独使用，也可与其他防老剂(如DNP、AP及其他非污染性防老剂)井用，可获得明显的协同效果。本品在橡胶中易分散，在日光下不变色，略有污染性。单独使用时用量一般为1-1.5份，当用量超过2份时，会产生晴霜现象。在乳胶泡沫橡胶中的用量为0.5份。因本晶有苦睐，不宜用于食品接触的橡胶制品中。
用作检定金、铋、镉、钴、汞、镍、铅、铊和锌的灵敏试剂及橡胶促进剂。

2-巯基苯并咪唑名称

[ CAS 号 ]:
583-39-1

[ 中文名 ]:
2-巯基苯并咪唑

[ 英文名 ]:
2-Mercaptobenzimidazole

[中文别名 ]:

[英文别名 ]:

2-Mercaptobenzimidazole
2,3-dihydro-1H-benzimidazole-2-thione
benzimidazole-2-thiol
2,3-dihydro-2-benzimidazolethione
2H-Benzimidazole-2-thione, 1,3-dihydro-
EINECS 209-502-6
2-Benzimidazolethiol
Vulkanox
Antigen MB
Nocrac MB

2-巯基苯并咪唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
332.1±25.0 °C at 760 mmHg

[ 熔点 ]:
300-304 °C(lit.)

[ 分子式 ]:
C₇H₆N₂S

[ 分子量 ]:
150.201

[ 闪点 ]:
154.7±23.2 °C

[ 精确质量 ]:
150.025162

[ PSA ]:
67.48000

[ LogP ]:
2.48

[ 外观性状 ]:
黄色或白色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.771

[ 储存条件 ]:
通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
<0.1 g/100 mL at 23.5 ºC

2-巯基苯并咪唑MSDS

详细MSDS(安全技术说明书)

2-巯基苯并咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE1050000

CHEMICAL NAME :: 2-Benzimidazolethiol

CAS REGISTRY NUMBER :: 583-39-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C7-H6-N2-S

MOLECULAR WEIGHT :: 150.21

WISWESSER LINE NOTATION :: T56 BM DNJ CSH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,990,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,990,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: 17(1),36,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04376 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6200 ug/m3/6H/13W-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Endocrine - changes in thyroid weight Blood - changes in erythrocyte (RBC) count

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,161,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1820 mg/kg/17W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 8(7),39,1964 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 660 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 25,218,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 110 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 25,218,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 330 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 25,218,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2477 No. of Facilities: 43 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 304 (estimated) No. of Female Employees: 67 (estimated)

2-巯基苯并咪唑安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312 + H332-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
DE1050000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933990090

2-巯基苯并咪唑合成路线

详细合成路线

2-巯基苯并咪唑上下游产品

2-巯基苯并咪唑上游产品

2-巯基苯并咪唑下游产品

2-巯基苯并咪唑制备

1.邻硝基苯胺的制备将熔融的邻硝基氯苯吸入高压釜内，再加入28%的氨水，密闭升温至170～175℃，搅拌反应7h，压力为3.5～4MPa。反应结束后，放氨泄压，氨气经冷却吸收制成氨水循环使用。待釜内温度降至100℃时，利用余压将釜内反应物压至沉析槽已备好的1000L水中。冷却至30℃以下，过滤，滤饼用少量冷水洗涤，即得邻硝基苯胺。收率95%～96%。

2.防老剂MB的制备在还原槽内加入邻硝基苯胺和21%的硫化钠溶液，升温至90℃，再密闭升温至105～110℃，压力自升为0.1～0.2MPa，搅拌还原5h，降温至30℃以下，再加入二硫化碳进行反应，温度保持在40℃左右，反应数小时后，升温回收二硫化碳。然后投入适量的碳酸氢钠溶液，加活性炭脱色、过滤，滤液用稀盐酸或稀硫酸酸化，2巯基苯并咪唑以固体析出。经离心分离、洗涤、干燥、粉碎，即得成品。

3.将64kg邻苯二胺、18kg氢氧化钾， 52kg二硫化碳依次加入反应釜中。开动搅拌，再加入480kg酒精，190kg蒸馏水缓缓加热，使其溶解后，继续加热回流3h。降温，停止沸腾后加入24kg活性炭回流20min，脱色。然后过滤除去活性炭。滤液放入结晶槽，加热至60～70℃，加热水300份。在搅拌下加入醋酸水溶液（30%～32%），使结晶完全。离心过滤，收集结晶于40 ℃下干燥，得成品。反应式如下：

2-巯基苯并咪唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-巯基苯并咪唑文献

Molecular interaction mechanism between 2-mercaptobenzimidazole and copper-zinc superoxide dismutase.

PLoS ONE 9(8) , e106003, (2014)

2-Mercaptobenzimidazole (MBI) is widely utilized as a corrosion inhibitor, copper-plating brightener and rubber accelerator. The residue of MBI in the environment is potentially harmful. In the presen...

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