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9-(2,2-二氰乙烯基)久洛啶

9-(2,2-二氰乙烯基)久洛啶用途

DCVJ(9-(2,2-二氰基乙烯基)茱萸内酯)是一种分子转子和独特的荧光染料,与微管蛋白和肌动蛋白结合,聚合后荧光强度显著增加。DCVJ还与磷脂双层结合并增加其荧光强度。DCVJ可以检测肥大细胞脱颗粒的动力学过程[1]。

9-(2,2-二氰乙烯基)久洛啶名称

[ CAS 号 ]:
58293-56-4

[ 中文名 ]:
9-(2,2-二氰乙烯基)久洛啶

[ 英文名 ]:
9-(2,2-Dicyanovinyl)julolidine

[英文别名 ]:

dcvj

9-(2,2-二氰乙烯基)久洛啶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288.

[2]. Furuno T, et al. A fluorescent molecular rotor probes the kinetic process of degranulation of mast cells. Immunol Lett. 1992;33(3):285-288.

9-(2,2-二氰乙烯基)久洛啶物理化学性质

[ 密度 ]:
1.23 g/cm3

[ 沸点 ]:
470.7ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₁₅N₃

[ 分子量 ]:
249.31000

[ 闪点 ]:
214.6ºC

[ 精确质量 ]:
249.12700

[ PSA ]:
50.82000

[ LogP ]:
2.88096

[ 外观性状 ]:
固体;Orange to Brown powder to crystal

[ 折射率 ]:
1.634

[ 储存条件 ]:
0-10°C;存放于惰性气体之中;避免空气,加热

9-(2,2-二氰乙烯基)久洛啶MSDS

详细MSDS(安全技术说明书)

9-(2,2-二氰乙烯基)久洛啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO4445000

CHEMICAL NAME :: Malononitrile, (2,3,6,7-tetrahydro-1H,5H-benzo(ij)quinolizin-9-ylmet hylene)-

CAS REGISTRY NUMBER :: 58293-56-4

BEILSTEIN REFERENCE NO. :: 0240710

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H15-N3

MOLECULAR WEIGHT :: 249.34

WISWESSER LINE NOTATION :: T666 1A M BNT&TJ H1UYCN&CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#08444

9-(2,2-二氰乙烯基)久洛啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
OO4445000

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9-(2,2-二氰乙烯基)久洛啶文献

Fluorescent molecular rotors: a new class of probes for tubulin structure and assembly.

Biochemistry 28 , 6678, (1989)

9-(Dicyanovinyl)julolidine (DCVJ) is a fluorescent dye whose intramolecular rotational relaxation is solvent dependent. Since its quantum yield increases with decreasing free volume, this molecule has...

9-(Dicyanovinyl)julolidine binding to bovine brain calmodulin.

J. Biochem. 109 , 499, (1991)

A molecular rotor, 9-(dicyanovinyl)julolidine (DCVJ), is a fluorescent dye whose intramolecular rotation determines its fluorescence yield [Kung, C.E. & Reed, J.K. (1989) Biochemistry 28, 6678-6686]. ...

Antibodies for fluorescent molecular rotors.

Biochemistry 32 , 7589, (1993)

We have prepared monoclonal antibodies for the fluorescent molecular rotors 9-(2-carboxy-2-cyanovinyl)julolidine (CCVJ) and 9-(dicyanovinyl)julolidine (DCVJ). Mouse monoclonal antibody (IgG2b) prepare...

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