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布地平

布地平用途

Budipine是一种抗帕金森病剂。

布地平名称

[ CAS 号 ]:
57982-78-2

[ 中文名 ]:
布地平

[ 英文名 ]:
1-tert-butyl-4,4-diphenylpiperidine

[中文别名 ]:

布地品

[英文别名 ]:

Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-
1-(1,1-Dimethylethyl)-4,4-diphenyl-piperidine
1-tert-butyl-4,4-diphenylpiperidine
1-(2-Methyl-2-propanyl)-4,4-diphenylpiperidine

布地平生物活性

[ 描述 ]:

Budipine是一种抗帕金森病剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Reichmann H, et al. Budipine in Parkinson's tremor. J Neurol Sci. 2006 Oct 25;248(1-2):53-5.

布地平物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
387.6±42.0 °C at 760 mmHg

[ 熔点 ]:
108.5°C

[ 分子式 ]:
C₂₁H₂₇N

[ 分子量 ]:
293.446

[ 闪点 ]:
168.7±24.8 °C

[ 精确质量 ]:
293.214355

[ PSA ]:
3.24000

[ LogP ]:
4.64

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
库房通风低温干燥,与食品原料类分开存放

布地平毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM7291100

CHEMICAL NAME :: Piperidine, 1-(1,1-dimethylethyl)-4,4-diphenyl-

CAS REGISTRY NUMBER :: 57982-78-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H27-N

MOLECULAR WEIGHT :: 293.49

WISWESSER LINE NOTATION :: T6NTJ AX1&1&1 DR& DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,85,1982

布地平安全信息

[ 海关编码 ]:
2933399090

布地平合成路线

详细合成路线

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布地平海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

布地平