Calmidazolium chloride

Calmidazolium chloride用途

Calmidazolium chloride (R 24571) 是一种钙调蛋白拮抗剂,拮抗CaM依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP酶活化, IC50 分别为0.15和0.35 μM。也用于抗癌研究。它结合CaMK的Kd 值为3 nM。

Calmidazolium chloride名称

[ CAS 号 ]:
57265-65-3

[ 中文名 ]:
Calmidazolium chloride

[ 英文名 ]:
Calmidazolium chloride

[英文别名 ]:

Calmidazolium chloride
COMPOUND 48/80 TRIHYDROCHLORIDE
COMPOUND 48/80
MFCD00077679
Calimidazoline
CALMIDAZOLIUM

Calmidazolium chloride生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 神经信号通路 >> 蛋白激酶

研究领域 >> 神经疾病

[ 靶点 ]

Kd: 3 nM (Calmodulin)[3]

[体外研究]

氯化咪唑鎓广泛用作钙调蛋白(CaM)拮抗剂,但也已知在某些癌细胞系中诱导细胞凋亡。氯化咪唑鎓(3,5,7,10μM,30分钟-24小时)抑制小鼠F9ECC的生长[2]。细胞活力测定[2]细胞系：小鼠F9 ECCs浓度：3,5,7,10μM孵育时间：30分钟-24小时结果：氯化咪唑铵处理的F9ECC和E14胚胎干细胞的IC50分别为8.18μM和12.69μM [2]。

[参考文献]

[1]. Gietzen K, et al. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem J. 1983 Dec 15;216(3):611-6.

[2]. Lee J, et al. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. Toxicol In Vitro. 2016 Sep;35:86-92.

[3]. Budu A, et al. Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.

Calmidazolium chloride物理化学性质

[ 沸点 ]:
724.9ºC at 760mmHg

[ 熔点 ]:
172-176ºC

[ 分子式 ]:
C₃₁H₂₃Cl₇N₂O

[ 分子量 ]:
687.698

[ 精确质量 ]:
683.963013

[ PSA ]:
18.04000

[ LogP ]:
7.29580

[ 储存条件 ]:
-20℃

Calmidazolium chlorideMSDS

详细MSDS(安全技术说明书)

Calmidazolium chloride安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

Calmidazolium chloride文献

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