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马尿酸乌洛托品

马尿酸乌洛托品用途

Methenamine hippurate (Hexamine hippurate) 是一种口服活性尿液抗菌剂,具有广泛的抗菌谱。Methenamine hippurate 对大多数常见的尿路病原体有效。

马尿酸乌洛托品名称

[ CAS 号 ]:
5714-73-8

[ 中文名 ]:
马尿酸乌洛托品

[ 英文名 ]:
Methenamine hippurate

[英文别名 ]:

Hippramine
Hexamethylenetetramine hippurate
R-657
Haiprex
Hexamethylenetetramine monohippurate
Viapta
hexamine hippurate
Methenamine hippurate

马尿酸乌洛托品生物活性

[ 描述 ]:

Methenamine hippurate (Hexamine hippurate) 是一种口服活性尿液抗菌剂,具有广泛的抗菌谱。Methenamine hippurate 对大多数常见的尿路病原体有效。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗感染 >> 细菌

[体外研究]

马尿酸甲酯是一种尿中释放甲醛并排泄在尿液中的抗菌剂。马尿酸甲胺在pH 5～6的体外对大肠杆菌、金黄色葡萄球菌、空气杆菌、铜绿假单胞菌和普通变形杆菌有明显的抑制作用,对肺炎克雷伯菌、铜绿假单胞菌、大肠杆菌、葡萄球菌有广泛的抑制作用。pH值为7.4的金黄色葡萄球菌和溶血性链球菌。这种作用比单独使用甲基苯丙胺、单独使用马尿酸或使用磺胺嘧啶[1]更有效。

[参考文献]

[1]. Forbes R, et al. ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial. Trials. 2018;19(1):616. Published 2018 Nov 9.

[2]. Gibson GR. A clinical appraisal of methenamine hippurate in urinary tract infections. Med J Aust. 1970;1(4):167‐170.

马尿酸乌洛托品物理化学性质

[ 沸点 ]:
464.1ºC at 760mmHg

[ 熔点 ]:
89-95ºC

[ 分子式 ]:
C₁₅H₂₁N₅O₃

[ 分子量 ]:
319.35900

[ 闪点 ]:
234.5ºC

[ 精确质量 ]:
319.16400

[ PSA ]:
79.36000

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
Refrigerator

马尿酸乌洛托品毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MR8159000

CAS REGISTRY NUMBER :: 5714-73-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H9-N-O3.C6-H12-N4

MOLECULAR WEIGHT :: 319.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2870 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82903 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 504 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82903 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

马尿酸乌洛托品安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport