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十六烷基三甲基溴化铵

十六烷基三甲基溴化铵用途

Cetrimonium溴是一种阳离子季胺盐表面活性剂, 是局部消毒剂Cetrimide的组成部分之一。

十六烷基三甲基溴化铵名称

[ CAS 号 ]:
57-09-0

[ 中文名 ]:
十六烷基三甲基溴化铵

[ 英文名 ]:
Hexadecyl trimethyl ammonium bromide

[中文别名 ]:

[英文别名 ]:

EINECS 200-311-3
cetyltrimethyl ammonium bromide
cetyl trimethylammonium bromide
cetrimonium bromide
CTMAB
Hexadecyltrimethylammonium bromide
CTAB
Lissolamine V
MFCD00011772
Varisoft CTB 40

十六烷基三甲基溴化铵生物活性

[ 描述 ]:

Cetrimonium溴是一种阳离子季胺盐表面活性剂, 是局部消毒剂Cetrimide的组成部分之一。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

十六烷基三甲基溴化铵物理化学性质

[ 熔点 ]:
248-251 °C(lit.)

[ 分子式 ]:
C₁₉H₄₂BrN

[ 分子量 ]:
364.448

[ 闪点 ]:
244 °C

[ 精确质量 ]:
363.250061

[ LogP ]:
3.17790

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Protect from moisture.

[ 水溶解性 ]:
13 g/L (20 ºC)

十六烷基三甲基溴化铵MSDS

详细MSDS(安全技术说明书)

十六烷基三甲基溴化铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BQ7875000

CHEMICAL NAME :: Ammonium, hexadecyltrimethyl-, bromide

CAS REGISTRY NUMBER :: 57-09-0

LAST UPDATED :: 199707

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C19-H42-N.Br

MOLECULAR WEIGHT :: 364.53

WISWESSER LINE NOTATION :: 16K1&1&1 &Q &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

REFERENCE :: BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951- Volume(issue)/page/year: 86,361,1972

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 40,668,1948 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 31,471,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 47,17,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 47,17,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,210,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,210,1966

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,40,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16380 mg/kg/1Y-C

TOXIC EFFECTS :: Gastrointestinal - other changes Musculoskeletal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 35,91,1976 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10500 ug/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 35 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10500 ug/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 35 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,331,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1981 No. of Facilities: 373 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 4695 (estimated) No. of Female Employees: 2068 (estimated)

十六烷基三甲基溴化铵安全信息

[ 符号 ]:

GHS05, GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H318-H335-H373-H400

[ 警示性声明 ]:
P260-P280-P301 + P312 + P330-P305 + P351 + P338 + P310

[ 靶器官 ]:
Gastrointestinal tract

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38;R50/53

[ 安全声明 (欧洲) ]:
S26-S39-S61-S37/39

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BQ7875000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
29239000

十六烷基三甲基溴化铵上下游产品

十六烷基三甲基溴化铵上游产品

十六烷基三甲基溴化铵下游产品

十六烷基三甲基溴化铵制备

1.先由十六醇和溴素在红磷催化作用下反应下制得溴代十六烷，再和三甲胺季铵反应即可。

2. 搅拌下将十六醇和红磷水浴加热混合溶解后，滴加溴，控制温度不超过100℃，加完后升温至100℃赶溴化氢气体，然后冷却，并将反应液倒入水中，搅拌使温度为30～40℃，静置分层，收集油层，用5%的碳酸钠溶液洗涤至中性，用无水硫酸钠干燥，过滤所得滤液减压蒸馏，收集1.33MPa下的191～210℃馏分，为溴代十六烷。先将三甲胺水溶液加热产生的三甲胺气体通入已过滤的工业丙酮中，制成三甲胺丙酮溶液（每升丙酮吸收67g三甲胺），然后加入溴代十六烷与丙酮的混合液（溴代十六烷∶丙酮＝ 1kg∶1L）。混合均匀后慢慢加热至30℃反应半小时，再慢慢加热至40℃。然后冷却结晶，过滤，抽干后，用丙酮泡洗结晶一次，再抽干，于80℃下干燥，即为成品。
过程反应式为:

4.主要采用季铵化法。以十六醇和氢溴酸为原料，在硫酸催化剂存在下，先进行溴化反应，生成溴代十六烷，然后与三甲胺进行季铵化反应而得。

5.溴化三甲基十六烷基铵有两种合成方法。将三甲胺制成丙酮溶液，在搅拌下滴加溴代十六烷，保温反应1h，冷却、结晶、提纯、甩干、干燥后即得产品。反应式如下：

也可用十六烷基二甲基铵和溴甲烷进行季铵化反应而制得。反应如下：

十六烷基三甲基溴化铵海关

[ 海关编码 ]: 29239000

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