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硫氰酸甲酯

硫氰酸甲酯用途

【用途一】
用于合成农药、医药及其他精细化学品。

硫氰酸甲酯名称

[ CAS 号 ]:
556-64-9

[ 中文名 ]:
硫氰酸甲酯

[ 英文名 ]:
methyl thiocyanate

[中文别名 ]:

硫氰酸甲基酯

[英文别名 ]:

methylthiomethanenitrile
Methyl Rhodanide
methylthiocyanate
Methylthiokyanat
thiocyanatomethane
Methyl sulfocyanate
EINECS 209-134-6
Methane,thiocyanato
methyl isothiocyanate
Methylrhodanid

硫氰酸甲酯物理化学性质

[ 密度 ]:
1.08

[ 沸点 ]:
131 °C

[ 熔点 ]:
-5 °C

[ 分子式 ]:
C₂H₃NS

[ 分子量 ]:
73.11690

[ 闪点 ]:
38 °C

[ 精确质量 ]:
72.99860

[ PSA ]:
49.09000

[ LogP ]:
0.83048

[ 外观性状 ]:
液体;Colorless to Light yellow clear liquid

[ 折射率 ]:
1.467-1.469

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放

[ 水溶解性 ]:
水溶性：实际上不溶；混溶：乙醚,醇

硫氰酸甲酯MSDS

硫氰酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XL1575000

CHEMICAL NAME :: Thiocyanic acid, methyl ester

CAS REGISTRY NUMBER :: 556-64-9

BEILSTEIN REFERENCE NO. :: 1098357

LAST UPDATED :: 199701

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C2-H3-N-S

MOLECULAR WEIGHT :: 73.12

WISWESSER LINE NOTATION :: NCS1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1036,1986

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2670 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 18,310,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 18,310,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 2,95,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 18,310,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02864

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 8500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 18,310,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 150,257,1930 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 448 mg/kg/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 18,310,1936 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7134 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 6721 (estimated) No. of Female Employees: 858 (estimated)

硫氰酸甲酯安全信息

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301 + H311 + H331-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R10;R23/24/25

[ 安全声明 (欧洲) ]:
S28A-S27-S26-S16-S45-S36/37/39

[ 危险品运输编码 ]:
UN1992

[ RTECS号 ]:
XL1575000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

硫氰酸甲酯合成路线

硫氰酸甲酯制备

由硫酸二甲酯与硫氰化钾反应而得。将硫氰化钾溶解于水，滴加硫酸二甲酯，控制温度在60℃以下，约3h滴加完毕。然后继续搅拌2h。放置过夜。取油层经水洗涤而制得成品。

硫氰酸甲酯文献

Olfactometry Profiles and Quantitation of Volatile Sulfur Compounds of Swiss Tilsit Cheeses.

J. Agric. Food Chem. 63 , 7511-21, (2015)

To establish the odor profiles of three differently fabricated commercial Swiss Tilsit cheeses, analyses were conducted using headspace solid-phase microextraction gas chromatography-mass spectrometry...

Infrared emission following photolysis of methylisothiocyanate and methylthiocyanate.

J. Phys. Chem. A 115(21) , 5319-23, (2011)

Methylisothiocyanate (CH(3)NCS) was photolyzed at 193 and 248 nm, and the resulting time-resolved infrared emission was observed. Similar experiments were performed on methylthiocyanate (CH(3)SCN) pho...

Quantification of methyl thiocyanate in the headspace of Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis patients by selected ion flow tube mass spectrometry.

Rapid Commun. Mass Spectrom. 25(17) , 2459-67, (2011)

Infection by Pseudomonas aeruginosa (PA) is a major cause of morbidity and mortality in patients with cystic fibrosis (CF). Breath analysis could potentially be a useful diagnostic of such infection, ...

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