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(-)-异丙肾上腺素(+)-酒石酸氢盐

(-)-异丙肾上腺素(+)-酒石酸氢盐用途

Isoproterenol tartrate, (-)- is a β-Adrenoceptor agonist; increases cytosolic cAMP.

(-)-异丙肾上腺素(+)-酒石酸氢盐名称

[ CAS 号 ]:
54750-10-6

[ 中文名 ]:
(-)-异丙基肾上腺素(+)酒石酸氢盐

[ 英文名 ]:
(-)-Isoproterenol tartrate

[中文别名 ]:

(-)-(+)-酒石酸异丙肾上腺素

[英文别名 ]:

(-Isoproterenol hydrogen tartrate salt
(-)-isoprenalinetartrate
isolevine
isoprenaline tartrate dihydrate
l-isoprenalinebitartrate
(-)-isoprenaline (+)-bitartrate salt
isopropylnoradrenalinebitartrate
isolevin

(-)-异丙肾上腺素(+)-酒石酸氢盐物理化学性质

[ 沸点 ]:
417.5ºCat 760 mmHg

[ 熔点 ]:
80-83ºC

[ 分子式 ]:
C₁₅H₂₃NO₉

[ 分子量 ]:
361.34400

[ 闪点 ]:
179.7ºC

[ 精确质量 ]:
361.13700

[ PSA ]:
187.78000

[ 外观性状 ]:
白色或灰白色粉末

(-)-异丙肾上腺素(+)-酒石酸氢盐MSDS

详细MSDS(安全技术说明书)

(-)-异丙肾上腺素(+)-酒石酸氢盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ8960000

CAS REGISTRY NUMBER :: 54750-10-6

LAST UPDATED :: 198912

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H17-N-O3.C4-H6-O6

MOLECULAR WEIGHT :: 361.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3768 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 21,1,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 849 mg/kg

TOXIC EFFECTS :: Vascular - regional or general arteriolar or venous dilation

REFERENCE :: SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 21,1,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930- Volume(issue)/page/year: 21,1,1953

(-)-异丙肾上腺素(+)-酒石酸氢盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

(-)-异丙肾上腺素(+)-酒石酸氢盐文献

Beta-adrenergic receptor activation facilitates induction of a protein synthesis-dependent late phase of long-term potentiation.

J. Neurosci. 25(13) , 3294-303, (2005)

Long-term potentiation (LTP) is activity-dependent enhancement of synaptic strength that can critically regulate long-term memory storage. Like memory, LTP exhibits at least two mechanistically distin...

Effects of noradrenaline on frequency tuning of rat auditory cortex neurons.

Eur. J. Neurosci. 9(4) , 833-47, (1997)

The selectivity of rat auditory cortex neurons for pure tone frequency was studied during and after ionophoretic application (5-40 nA) of noradrenaline in urethane-anaesthetized rats. The dominant eff...

[Effect of synaptically active substances on the hyperthermic effect of prostaglandin E2 in rats].

Biull. Eksp. Biol. Med. 91(3) , 304-5, (1981)

It was established in experiments on unanesthetized rats given intraventricular injections of drugs that hyperthermic effect of prostaglandin E2 (PGE2) was markedly weakened by administering clofelin ...

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