二氯甲基醚
二氯甲基醚用途
1.作药物消瘤芥、八氮二丙醚、双解磷的中间体。也是维生素B2的中间体（合成3,4-二甲基苯胺的原料）。
2.用于有机合成；医药工业用于合成抗肿瘤药淄瘤芥、解毒药物双复磷等。
3.工业上用作甲基化剂、试剂和制造离子交换树脂的中间体。
二氯甲基醚名称
[ CAS 号 ]:
542-88-1
[ 中文名 ]:
二氯甲基醚
[ 英文名 ]:
BIS(CHLOROMETHYL) ETHER
[英文别名 ]:
- dichlorodimethyl ether
- Methane,oxybis[chloro
- bis(chloromethyl)-ether
- BCME
- BIS(CHLOROMETHYL) ETHER
- Chloro(chloromethoxy)methane
- dicarbonyl chloride
- di(chloromethyl)ether
- Methane, 1,1'-oxybis[1-chloro-
- monochloromethyl ether
二氯甲基醚物理化学性质
[ 密度 ]:
1.3±0.1 g/cm3
[ 沸点 ]:
106.0±0.0 °C at 760 mmHg
[ 熔点 ]:
-41.5ºC
[ 分子式 ]:
C2H4Cl2O
[ 分子量 ]:
114.959
[ 闪点 ]:
74.8±19.8 °C
[ 精确质量 ]:
113.963921
[ PSA ]:
9.23000
[ LogP ]:
0.67
[ 蒸汽压 ]:
33.6±0.1 mmHg at 25°C
[ 折射率 ]:
1.416
[ 储存条件 ]:
库房通风低温干燥,与氧化剂,及食品分开储运
二氯甲基醚MSDS
二氯甲基醚毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KN1575000
- CHEMICAL NAME :
- Ether, bis(chloromethyl)
- CAS REGISTRY NUMBER :
- 542-88-1
- BEILSTEIN REFERENCE NO. :
- 1679223
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 56
- MOLECULAR FORMULA :
- C2-H4-Cl2-O
- MOLECULAR WEIGHT :
- 114.96
- WISWESSER LINE NOTATION :
- G1O1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3 ppm
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 100 ppm/3M
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7 ppm/7H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/m3/6H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 280 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 7 ppm/7H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - hemorrhage
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ppb/6H/4W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 375 mg/kg/43W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 ppb/6H/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5520 mg/kg/23W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg/61W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 384 mg/kg/42W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 640 mg/kg/53W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ppb/6H/6W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - hair
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 ppb/6H/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 ppm/82D-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - increased incidence of tumors in susceptible strains
- TYPE OF TEST :
- TC - Toxic concentration (other than lowest)
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75 ppb/6H/2Y-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11 gm/kg/44W-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Kidney
- REFERENCE :
- BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 37,873,1978 *** REVIEWS *** ACGIH TLV-Confirmed human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.0047 mg/m3 (0.001 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,231,1974 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,231,1974 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,131,1987 TOXICOLOGY REVIEW ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC. Volume(issue)/page/year: 166,113,1978 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Construc):see CFR 29,1926.1108 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1008,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.001 ppm (0.006 mg/m3);Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.001 ppm (0.0047 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-FINLAND:TWA 0.001 ppm (0.004 mg/m3);STEL 0.003 ppm;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.001 ppm (0.006 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-INDIA:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.001 ppm JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.001 ppm (0.005 mg/m3);Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.001 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BIS(CHLOROMETHYL) ETHER-air:CA use 29 CFR 1910.1008 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6315 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated) No. of Female Employees: 5 (estimated)
二氯甲基醚安全信息
[ 危害码 (欧洲) ]:
T+
[ 风险声明 (欧洲) ]:
10-36/37/38-40-26-24-22-45
[ 安全声明 (欧洲) ]:
26-36/37/39-45-53
[ 危险品运输编码 ]:
2249
[ WGK德国 ]:
3
[ RTECS号 ]:
QK3930000
[ 包装等级 ]:
I
[ 危险类别 ]:
6.1(a)
[ 海关编码 ]:
29309070
二氯甲基醚上下游产品
二氯甲基醚上游产品
二氯甲基醚下游产品
二氯甲基醚制备
1.由多聚甲醛经氯化而得。
2.制法：
于装有搅拌器、温度计、滴液漏斗的反应瓶中，加入1.0kg(31.25mol)多聚甲醛（2）、250g浓盐酸，冰水浴冷却至10℃以下，搅拌下慢慢滴加氯磺酸3.9kg，控制滴加速度保持反应温度在10℃左右。加完后室温搅拌反应4h。放置过夜。分出上层溶液，用冰水洗涤两次，再用40%的氢氧化钠溶液及少量碎冰洗涤，固体氢氧化钠干燥。常压分馏，收集100～105℃的馏分，得a，a′-二氯二甲醚①（1）2.3kg，收率65%。注：①该化合物为剧毒品，并有致癌作用，使用时应特别注意安全。
二氯甲基醚海关
[ 海关编码 ]: 2909199090
[ 中文概述 ]:
2909199090. 其他无环醚及其卤化衍生物（包括磺化，硝化或亚硝化衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
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