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3,4-二氨基吡啶

3,4-二氨基吡啶用途

Amifampridine可作用于罕见的肌肉疾病。

3,4-二氨基吡啶名称

[ CAS 号 ]:
54-96-6

[ 中文名 ]:
5-(戊烷-3-基氧基)-7-氧杂双环(4.1.0)庚-3-烯-3-羧酸乙酯

[ 英文名 ]:
3,4-Diaminopyridine

[中文别名 ]:

[英文别名 ]:

3-Pyridinamine, 1,4-dihydro-4-imino-
3,4-Pyridinedramine
3,4-DIAMINOPYRIDINE FOR SYNTHESIS
3,4-Diaminopyridin
3,4-DAP
3,4-diamino-pyridine
3,4-diamino-pyridin
3,4-Diaminopyridine
Amifampridine
3 4-DIAMINOPYRIDINE

3,4-二氨基吡啶生物活性

[ 描述 ]:

Amifampridine可作用于罕见的肌肉疾病。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[参考文献]

[1]. http://en.wikipedia.org/wiki/3,4-Diaminopyridine#cite_note-4

[相关活性小分子]

3,4-二氨基吡啶物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
369.3±22.0 °C at 760 mmHg

[ 熔点 ]:
216-218 °C(lit.)

[ 分子式 ]:
C₅H₇N₃

[ 分子量 ]:
109.129

[ 闪点 ]:
204.9±9.5 °C

[ 精确质量 ]:
109.063995

[ PSA ]:
64.93000

[ LogP ]:
-0.09

[ 外观性状 ]:
略米色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.676

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
24 g/L (20 ºC)

3,4-二氨基吡啶MSDS

3,4-二氨基吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7600000

CHEMICAL NAME :: Pyridine, 3,4-diamino-

CAS REGISTRY NUMBER :: 54-96-6

BEILSTEIN REFERENCE NO. :: 0110232

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H7-N3

MOLECULAR WEIGHT :: 109.15

WISWESSER LINE NOTATION :: T6NJ CZ DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,296,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 150,413,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 26,345,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

3,4-二氨基吡啶安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H330-H311-H315-H319-H335

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R25;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45-S37/39-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
US7600000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29333999

3,4-二氨基吡啶合成路线

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3,4-二氨基吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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