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硫柳汞钠

硫柳汞钠用途

硫柳汞是一种含汞疫苗防腐剂,是神经发育障碍病因中的可疑因素。

硫柳汞钠名称

[ CAS 号 ]:
54-64-8

[ 中文名 ]:
硫柳汞

[ 英文名 ]:
Thiomersal

[中文别名 ]:

乙汞硫柳酸鈉

[英文别名 ]:

Thimersalate
MFCD00013062
Thiomersalate
sodium,(2-carboxylatophenyl)sulfanyl-ethylmercury
Thimerosalate
Merthiolate sodium
Thiomersal
Thimerosal
MERTHIOLATE
sodium salt of (2-carboxyphenylthio)ethylmercury

硫柳汞钠生物活性

[ 描述 ]:

硫柳汞是一种含汞疫苗防腐剂,是神经发育障碍病因中的可疑因素。

[ 相关类别 ]:

研究领域 >> 神经疾病

[体内研究]

硫柳汞(THIM)给药以剂量依赖性方式增加中脑导水管周围灰质(PAG)中的μ-阿片受体(MOR)密度。高剂量硫柳汞治疗显著增加中脑导水管周围灰质背内侧区(DMPAG)和中脑导水管周围灰质外侧区(LPAG)的MOR密度。在剂量为3000μg Hg/kg时,硫柳汞还会增加尾壳核(CPU)中的MOR密度。相反,两种较高剂量的硫柳汞均能降低齿状回(DG)的MOR密度[1]。硫柳汞给药(出生后第7、9、11、15天注射4次,即240μg Hg/kg)可引起氨基酸溢出的持续变化：谷氨酸和天冬氨酸增加,同时甘氨酸和丙氨酸减少；注射后10至14周测量。微透析时,以12.5μg Hg/kg的剂量四次注射硫柳汞不会改变谷氨酸和天冬氨酸的浓度。在灌注液中将硫柳汞应用于前额叶皮质(PFC)会引起谷氨酸溢出的快速增加。神经甾体、硫酸脱氢表雄酮(DHEAS；80mg/kg；i、防止硫柳汞对谷氨酸和天冬氨酸的影响；单用类固醇对这些氨基酸没有影响。在灌注液中同时应用硫酸脱氢表雄酮(DHEAS)和硫柳汞也可阻断硫柳汞对谷氨酸的急性作用[2]。

[动物实验]

本研究采用雄性大鼠。在出生后第20周，动物被戊巴比妥过量安乐死，然后斩首。用两种更高剂量的硫柳汞（THIM）（1440和3000μg Hg/kg）治疗的大鼠来自原始幼仔，用于不同的行为和病理测试，但在实验上是幼稚的。根据相同的程序，在出生后第8周处死一组单独的实验性天真大鼠，用两种较低剂量的硫柳汞（12和240μg Hg/kg）（每种药物治疗4窝）治疗。每个实验组由5只动物组成，最多2只来自同一窝动物[1]。

[参考文献]

[1]. Olczak M, et al. Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the ratbrain. Neurochem Res. 2010 Nov;35(11):1840-7.

[2]. Duszczyk-Budhathoki M, et al. Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate. Neurochem Res. 2012 Feb;37(2):436-47.

硫柳汞钠物理化学性质

[ 沸点 ]:
298.6ºC at 760mmHg

[ 熔点 ]:
234-237 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₉HgNaO₂S

[ 分子量 ]:
404.811

[ 闪点 ]:
250 °C

[ 精确质量 ]:
405.992706

[ PSA ]:
65.43000

[ LogP ]:
1.57790

[ 外观性状 ]:
淡黄色粉末

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

[ 稳定性 ]:
Stable. May degrade in sunlight. Incompatible with strong acids, strong bases, strong oxidizing agents, iodine, heavy metal salts.

[ 水溶解性 ]:
1 G/ML (20 ºC)

硫柳汞钠MSDS

详细MSDS(安全技术说明书)

硫柳汞钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OV8400000

CHEMICAL NAME :: Mercury, ((o-carboxyphenyl)thio)ethyl-, sodium salt

CAS REGISTRY NUMBER :: 54-64-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 52

MOLECULAR FORMULA :: C9-H9-Hg-O2-S.Na

MOLECULAR WEIGHT :: 404.82

WISWESSER LINE NOTATION :: QVR BS-HG-2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraaural

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 60 mg/kg/4W-I

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - metabolic acidosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 98 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 91 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 54 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 104 mg/kg/1Y-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 104 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 130 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1300 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

DOSE :: 112 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Ocular

DOSE :: 65 ug/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 287,29,1993 *** REVIEWS *** ACGIH TLV-TWA 0.1 mg(Hg)/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.05 mg(Hg)/m3 DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,22,1973 OSHA PEL (Gen Indu):8H TWA 0.01 mg(Hg)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.01 mg(Hg)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.01 mg(Hg)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.01 mg(Hg)/m3 (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.05 mg(Hg)/m3;Skin JAN 1993 OEL-BELGIUM:TWA 0.05 mg(Hg)/m3;Skin JAN 1993 OEL-DENMARK:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-FINLAND:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-FRANCE:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-GERMANY:TWA 0.01 ppm (0.1 mg(Hg)/m3) JAN 1993 OEL-HUNGARY:TWA 0.02 mg(Hg)/m3;STEL 0.04 mg(Hg)/m3 JAN 1993 OEL-JAPAN:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-POLAND:TWA 0.01 mg(Hg)/m3 JAN 1993 OEL-RUSSIA:TWA 0.05 mg(Hg)/m3;STEL 0.01 mg(Hg)/m3 JAN 1993 OEL-SWEDEN:TWA 0.05 mg(Hg)/m3 JAN 1993 OEL-THAILAND:STEL 0.05 mg(Hg)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.05 mg(Hg)/m3;STEL 0.15 mg(Hg)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84569 No. of Facilities: 5617 (estimated) No. of Industries: 83 No. of Occupations: 30 No. of Employees: 242717 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84569 No. of Facilities: 3695 (estimated) No. of Industries: 32 No. of Occupations: 41 No. of Employees: 152997 (estimated) No. of Female Employees: 114190 (estimated)

硫柳汞钠安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330-H373-H410

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P260-P262-P280-P302 + P352 + P310-P304 + P340 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;N:Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R26/27/28;R33;R50/53

[ 安全声明 (欧洲) ]:
S13-S28-S36-S45-S60-S61-S28A

[ 危险品运输编码 ]:
UN 2025 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
OV8400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
29310095

硫柳汞钠制备

由磷硫羟苯甲酸与氯化乙汞反应制得

硫柳汞钠海关

[ 海关编码 ]: 29310095

硫柳汞钠文献

Safety review: squalene and thimerosal in vaccines.

Therapie. 65(6) , 533-41, (2010)

Few studies show the reluctance of the people to get vaccinated against A (H1N1) influenza for fear of side effects of squalene (MF59, AS03, AF03) and thimerosal. The aim of this paper is to assess th...

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.

Arch. Toxicol. 89 , 1599-618, (2015)

Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a rel...

Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules.

Autophagy 10(9) , 1666-80, (2014)

It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidenc...

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