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ACTH(18-39)(人类)

ACTH(18-39)(人类)用途

Adrenocorticotropic Hormone (ACTH) (18-39), human 是一种似皮质促素中叶肽,产生于垂体中叶的促黑素细胞。

ACTH(18-39)(人类)名称

[ CAS 号 ]:
53917-42-3

[ 中文名 ]:
促肾上腺皮质激素(ACTH)(18-39),人

[ 英文名 ]:
ACTH (18-39) (human)

[英文别名 ]:

CLIP
ProteoMass™ ACTH Fragment 18-39 MALDI-MS
Adrenocorticotropic hormone fragment 18-39
ACTH (18-39) (HUMAN)
Adrenocorticotropic Hormone (ACTH) (18-39), human

ACTH(18-39)(人类)生物活性

[ 描述 ]:

Adrenocorticotropic Hormone (ACTH) (18-39), human 是一种似皮质促素中叶肽,产生于垂体中叶的促黑素细胞。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

多肽产品

[体外研究]

ACTH家族多肽由ACTH(1-39)(促肾上腺皮质激素),ACTH(1-13)酰胺(α-胰蛋白酶原;α-MSH)组成;和ACTH(18-39)(促肾上腺皮质激素样中间叶肽,CLIP)。这些多肽衍生自普通前体proopiomelanocortin。在远端的皮质细胞中,原阿黑皮素(POMC)经历一系列蛋白水解切割反应以产生作为主要终产物的ACTH(1-39)。然而,在中间体的中性细胞中,另外一组蛋白水解反应导致ACTH(1-39)转化为ACTH(1-13)酰胺和ACTH(18-39)。在几种脊椎动物中,ACTH(1-13)酰胺经历最终产物修饰,产生α-和二乙酰化形式的α-MSH作为中间体的主要终产物[1]。

[参考文献]

[1]. Dores RM, et al. Analysis of ACTH-related and CLIP-related peptides partially purified from the pituitary of the Australian lungfish, Neoceratodus forsteri. Gen Comp Endocrinol. 1990 Jul;79(1):64-73.

[相关活性小分子]

ACTH(18-39)(人类)物理化学性质

[ 密度 ]:
1.49g/cm3

[ 分子式 ]:
C₁₁₂H₁₆₅N₂₇O₃₆

[ 分子量 ]:
2465.67000

[ 精确质量 ]:
2464.19000

[ PSA ]:
1006.02000

[ LogP ]:
1.91620

[ 折射率 ]:
1.665

[ 储存条件 ]:
-20℃

ACTH(18-39)(人类)MSDS

详细MSDS(安全技术说明书)

ACTH(18-39)(人类)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

ACTH(18-39)(人类)文献

Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.

Nat. Commun. 5 , 5369, (2014)

Immunodominant epitopes are few selected epitopes from complex antigens that initiate T-cell responses. Here to provide further insights into this process, we use a reductionist cell-free antigen-proc...

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility.

J. Immunol. 194(4) , 1446-53, (2015)

B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear proteins within autophagosomes. Fusion of autophagosomes with lysosomes and endosomes facilitates content proteolysis, with the ...

Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography.

J. Chromatogr. A. 1356 , 289-93, (2014)

An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clinda...

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