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去甲托品醇

去甲托品醇用途

Nortropine (Nortropenol) 可从 Convolvulus subhirsutus 生物碱中分离得到,是托品碱分解和反应生成琥珀酸的中间体。

去甲托品醇名称

[ CAS 号 ]:
538-09-0

[ 中文名 ]:
去甲托品醇

[ 英文名 ]:
8-Aza-bicyclo[3.2.1]octan-3-ol HCl

[中文别名 ]:

[英文别名 ]:

β-Phenylethyl alcohol
b-Phenylethanol
β-Phenylethanol
3a-Nortropanol
2-Hydroxyethylbenzene
Phenylethyl alcohol (USP)
endo-8-azabicyclo(3.2.1)octan-3-ol hydrochloride
β-phenylethyl alcoho
8-Aza-bicyclo[3.2.1]octan-3-ol HCl
b-pea

去甲托品醇生物活性

[ 描述 ]:

Nortropine (Nortropenol) 可从 Convolvulus subhirsutus 生物碱中分离得到,是托品碱分解和反应生成琥珀酸的中间体。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Bartholomew BA, et al. Atropine Metabolism by Pseudomonas sp. Strain AT3: Evidence for Nortropine as an Intermediate in Tropine Breakdown and Reactions Leading to Succinate. Appl Environ Microbiol. 1996 Sep;62(9):3245-50.

[2]. A. M. Gapparov, et al. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chemistry of Natural Compounds. 2007. 43(3):291-292.

去甲托品醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
218.2±8.0 °C at 760 mmHg

[ 熔点 ]:
108-110ºC

[ 分子式 ]:
C₇H₁₃NO

[ 分子量 ]:
122.164

[ 闪点 ]:
102.2±0.0 °C

[ 精确质量 ]:
122.073166

[ PSA ]:
40.46000

[ LogP ]:
1.36

[ 外观性状 ]:
淡黄褐色的固体

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.536

[ 储存条件 ]:
室温，密封，干燥

去甲托品醇MSDS

详细MSDS(安全技术说明书)

去甲托品醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD0700000

CHEMICAL NAME :: 1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol

CAS REGISTRY NUMBER :: 538-09-0

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H13-N-O

MOLECULAR WEIGHT :: 127.21

WISWESSER LINE NOTATION :: T56 A AMTJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 145,97,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANCPAC Annales de Chimie. (Masson et Cie, Paris, France) V.9-15, 1914-77. Volume(issue)/page/year: 7,537,1962

去甲托品醇安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933990090

去甲托品醇合成路线

详细合成路线

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去甲托品醇海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%