氨基磺酸

氨基磺酸用途

【用途一】
用于除草剂、防火剂、纸张和纺织品的软化剂、金属清洗剂等
【用途二】
用于防莠剂的制备、织物的防火及有机合成
【用途三】
在分析化学中可作为酸碱滴定的基准试剂。也用作除草剂、防火剂，纸张和纺织品的软化剂，纤维的防缩、漂白、柔软剂，金属和陶瓷的清洁剂，合成尿醛树脂的催化剂。还用于染料的重氮化和电镀金属的酸洗。
【用途四】
作漂白助剂。可减少或消除漂液中重金属离子的催化作用，从而使漂液质量得到保证，并能减少金属离子对纤维的氧化降解作用。亦能阻止纤维的剥皮反应，提高纸浆强度、白度。应用时注意不能将其直接放入漂液中，而就先用水溶解后再中入漂液中。
【用途五】
氨基磺酸是一种固态的一元无机酸，也可看成是硫酸的一酰胺、磺酰胺酸、胺磺酸。它是一种硫酸单酰胺化合物，由于具有氨基和磺酸基双官能团，能进行各种化学反应，是一种十分重要的精细化学品。用作除草剂、防火剂，金属和陶瓷的清洁剂，纸张和纺织品的软化剂及漂白剂，合成脲醛树脂的催化剂，在偶氮染料生产中作除腈剂，在游泳池中作氯化和漂白液的稳定剂等。在分析化学中作为酸碱滴定的基准试剂。
【用途六】
碱量滴定法标准，络合掩蔽剂，有机微量分析测定氮和硫的标准

氨基磺酸名称

[ CAS 号 ]:
5329-14-6

[ 中文名 ]:
氨基磺酸

[ 英文名 ]:
Sulfamic acid

[中文别名 ]:

磺酰胺酸

[英文别名 ]:

nitrilosulphonic acid
Jumbo
Amino sulfonic acid
Sulphamic acid
Sulfaminic acid
aminosulfonic acid
MFCD00011603
amidosulfonic acid
Amidosulfuric acid
EINECS 226-218-8

氨基磺酸物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
247ºC

[ 熔点 ]:
215-225 °C (dec.)(lit.)

[ 分子式 ]:
H₃NO₃S

[ 分子量 ]:
97.094

[ 闪点 ]:
205ºC

[ 精确质量 ]:
96.983360

[ PSA ]:
88.77000

[ LogP ]:
-1.42

[ 外观性状 ]:
白色结晶固体

[ 折射率 ]:
1.544

[ 储存条件 ]:
库房通风低温干燥,与碱、氧化剂分开存放

[ 稳定性 ]:
Stable.

[ 水溶解性 ]:
146.8 g/L (20 ºC)

氨基磺酸MSDS

详细MSDS(安全技术说明书)

氨基磺酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO5950000

CHEMICAL NAME :: Sulfamic acid

CAS REGISTRY NUMBER :: 5329-14-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: H3-N-O3-S

MOLECULAR WEIGHT :: 97.10

WISWESSER LINE NOTATION :: ZSWQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,26,1943

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,18,1972

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,26,1943

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,18,1972 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,18,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,26,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1312 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Behavioral - rigidity (including catalepsy)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(10),88,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Behavioral - rigidity (including catalepsy)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(10),88,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82834 No. of Facilities: 5516 (estimated) No. of Industries: 78 No. of Occupations: 54 No. of Employees: 56781 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82834 No. of Facilities: 6660 (estimated) No. of Industries: 89 No. of Occupations: 74 No. of Employees: 133549 (estimated) No. of Female Employees: 30034 (estimated)

氨基磺酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H412

[ 警示性声明 ]:
P273-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/38;R52/53

[ 安全声明 (欧洲) ]:
S26-S28-S61-S28A

[ 危险品运输编码 ]:
UN 2967 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
WO5950000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2922210000

氨基磺酸合成路线

详细合成路线

氨基磺酸上下游产品

氨基磺酸上游产品

氨基磺酸下游产品

氨基磺酸制备

1.氨基磺酸的生产方法很多，有二氧化硫与羟胺或丙酮肟为原料的羟胺法，亚硫酸或硫酸盐与液氨为原料的氨化法，尿素与氯磺酸为原料的氯磺化法，以发烟硫酸和尿素为原料的发烟硫酸法，尿素、三氧化硫和硫酸为原料的硫酸法和发烟硫酸法（又称液相法）和液氨经气化与三氧化硫在气相条件下反应的气相法等。目前国内外具有工业意义的工艺为发烟硫酸法以及三氧化硫与氨直接合成的氨化法两种。由尿素与发烟硫酸在40-70℃下进行磺化生成氨基磺酸粗品，然后加水进行结晶制得氨基磺酸成品。原料消耗定额：尿素2000kg/t、发烟硫酸1500kg/t。

2.其合成方法主要有气相法和液相法两种。气相法操作条件苛刻，设备材质要求高。副产品多，且氨基酸易粘附在反应器内壁需经常清理。生产成本高。优点是产品纯度高。目前厂家采用的多为液相法。

3.将过量的发烟硫酸加入反应釜中，搅拌降温至20～40 ℃，开始加入按比例混合好的硫酸和尿素。加料结束后，在20 ℃左右搅拌8 h。再逐渐升温至70～90 ℃，蒸出三氧化硫，冷却析晶。固液分享后得粗氨基磺酸，用水重结晶，脱水干燥得高纯度精品氨基磺酸。反应式如下：

4.氨基磺酸是强Lewis酸SO3与强Lewis碱NH3的加合物，制取少量纯度要求高的氨基磺酸时，可在完全无水的条件下，直接用高纯度的SO3与氨反应。若用量较大时可用尿素与发烟硫酸反应来制取。将带有机械搅拌装置的圆底烧瓶置于流水浴中，向其中加入560g 100%的硫酸，在强烈搅拌下将100g尿素分多次（约45min加完）慢慢加入到硫酸中，注意不要使温度超过40℃。然后向其中加入309g发烟硫酸（含65%游离SO3），并在42～45℃的温度下放置16h。用玻璃砂芯漏斗过滤反应混合物，先用纯硫酸洗涤，再用50%的硫酸洗涤，最后用冷的甲醇洗涤。

5.将20%的发烟硫酸加热至30℃，慢慢加入尿素，温度控制在60～65℃，加完后保温3H，然后升温至80～85℃，保温2h，进行磺化反应：

反应结束后，冷却至5℃，过滤，所得结晶离心甩干后，用5%乙醇洗涤，滤干后用蒸馏水重结晶精制，得氨基磺酸纯品。

氨基磺酸海关

[ 海关编码 ]: 2922210000

氨基磺酸文献

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Bioorg. Med. Chem. 20 , 1403-10, (2012)

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Comparison of a novel extraction-based colorimetric (ABTS) method with membrane introduction mass spectrometry (MIMS): trichloramine dynamics in pool water.

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Trichloramine is a hazardous disinfection by-product, which is present in chlorinated swimming pools. Although it is primarily taken up by inhalation, the concentration in pool water is important to m...

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